Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts

Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts

Abstract Background Late-stage breast cancer preferentially metastasises to bone; despite advances in targeted therapies, this condition remains incurable. The lack of clinically relevant models for studying breast cancer metastasis to a human bone microenvironment has stunted the development of eff...

Full description

Bibliographic Details
Main Authors: Diane Lefley, Faith Howard, Fawaz Arshad, Steven Bradbury, Hannah Brown, Claudia Tulotta, Rachel Eyre, Denis Alférez, J. Mark Wilkinson, Ingunn Holen, Robert B. Clarke, Penelope Ottewell
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Bone metastasis
ER+
ER−
PDX
Online Access:https://doi.org/10.1186/s13058-019-1220-2

Internet

https://doi.org/10.1186/s13058-019-1220-2

Similar Items