Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts

Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts

Abstract Background Late-stage breast cancer preferentially metastasises to bone; despite advances in targeted therapies, this condition remains incurable. The lack of clinically relevant models for studying breast cancer metastasis to a human bone microenvironment has stunted the development of eff...

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Bibliographic Details
Main Authors: Diane Lefley, Faith Howard, Fawaz Arshad, Steven Bradbury, Hannah Brown, Claudia Tulotta, Rachel Eyre, Denis Alférez, J. Mark Wilkinson, Ingunn Holen, Robert B. Clarke, Penelope Ottewell
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Bone metastasis
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Online Access:https://doi.org/10.1186/s13058-019-1220-2

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