Flavonoid Compounds Contained in Epimedii Herba Inhibit Tumor Progression by Suppressing STAT3 Activation in the Tumor Microenvironment

M2-like tumor-associated macrophages (TAMs) in the tumor tissues promote tumor progression by various mechanisms and represent possible targets of antitumor therapy. In the present study, we tested whether compounds from Epimedii Herba inhibit macrophage polarization to the M2/protumorigenic phenoty...

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Bibliographic Details
Main Authors: Cheng Pan, Yukio Fujiwara, Hasita Horlad, Daisuke Shiraishi, Toyohisa Iriki, Jyunko Tsuboki, Tsuyoshi Ikeda, Yoshihiro Komohara
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00262/full