Liposomal packaging generates Wnt protein with in vivo biological activity.

Liposomal packaging generates Wnt protein with in vivo biological activity.

Wnt signals exercise strong cell-biological and regenerative effects of considerable therapeutic value. There are, however, no specific Wnt agonists and no method for in vivo delivery of purified Wnt proteins. Wnts contain lipid adducts that are required for activity and we exploited this lipophilic...

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Bibliographic Details
Main Authors: Nathan T Morrell, Philipp Leucht, Ludan Zhao, Jae-Beom Kim, Derk ten Berge, Karthik Ponnusamy, A Lyonel Carre, Henryk Dudek, Marie Zachlederova, Michael McElhaney, Shirley Brunton, Janet Gunzner, Marinella Callow, Paul Polakis, Mike Costa, Xiaoyan M Zhang, Jill A Helms, Roel Nusse
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2515347?pdf=render

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http://europepmc.org/articles/PMC2515347?pdf=render

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