Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2

Summary: An inducible gene expression program is a hallmark of the host inflammatory response. Recently, long intergenic non-coding RNAs (lincRNAs) have been shown to regulate the magnitude, duration, and resolution of these responses. Among these is lincRNA-Cox2, a dynamically regulated gene that b...

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Bibliographic Details
Main Authors: Roland Elling, Elektra K. Robinson, Barbara Shapleigh, Stephen C. Liapis, Sergio Covarrubias, Sol Katzman, Abigail F. Groff, Zhaozhao Jiang, Shiuli Agarwal, Mona Motwani, Jennie Chan, Shruti Sharma, Elizabeth J. Hennessy, Garret A. FitzGerald, Michael T. McManus, John L. Rinn, Katherine A. Fitzgerald, Susan Carpenter
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718316036