Fcγ receptor-mediated influx of S100A8/A9-producing neutrophils as inducer of bone erosion during antigen-induced arthritis

Fcγ receptor-mediated influx of S100A8/A9-producing neutrophils as inducer of bone erosion during antigen-induced arthritis

Abstract Background Osteoclast-mediated bone erosion is a central feature of rheumatoid arthritis (RA). Immune complexes, present in a large percentage of patients, bind to Fcγ receptors (FcγRs), thereby modulating the activity of immune cells. In this study, we investigated the contribution of FcγR...

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Bibliographic Details
Main Authors: Irene Di Ceglie, Giuliana Ascone, Niels A. J. Cremers, Annet W. Sloetjes, Birgitte Walgreen, Thomas Vogl, Johannes Roth, J. Sjef Verbeek, Fons A. J. van de Loo, Marije I. Koenders, Peter M. van der Kraan, Arjen B. Blom, Martijn H. J. van den Bosch, Peter L. E. M. van Lent
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Arthritis Research & Therapy
Subjects:
Experimental arthritis
Bone erosion
Osteoclast
Immune complexes
FcγRs
Neutrophils
Online Access:http://link.springer.com/article/10.1186/s13075-018-1584-1

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http://link.springer.com/article/10.1186/s13075-018-1584-1

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