Bid participates in genotoxic drug-induced apoptosis of HeLa cells and is essential for death receptor ligands' apoptotic and synergistic effects.

<h4>Background</h4>The BH3-only protein Bid is an important component of death receptor-mediated caspase activation. Bid is cleaved by caspase-8 or -10 into t-Bid, which translocates to mitochondria and triggers the release of caspase-activating factors. Bid has also been reported to be...

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Bibliographic Details
Main Authors: Barbara Köhler, Sergio Anguissola, Caoimhin G Concannon, Markus Rehm, Donat Kögel, Jochen H M Prehn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-07-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18665234/pdf/?tool=EBI