Human RPA activates BLM’s bidirectional DNA unwinding from a nick

Human RPA activates BLM’s bidirectional DNA unwinding from a nick

BLM is a multifunctional helicase that plays critical roles in maintaining genome stability. It processes distinct DNA substrates, but not nicked DNA, during many steps in DNA replication and repair. However, how BLM prepares itself for diverse functions remains elusive. Here, using a combined singl...

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Bibliographic Details
Main Authors: Zhenheng Qin, Lulu Bi, Xi-Miao Hou, Siqi Zhang, Xia Zhang, Ying Lu, Ming Li, Mauro Modesti, Xu-Guang Xi, Bo Sun
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-02-01
Series:eLife
Subjects:
BLM
RPA
helicase
single molecule
optical tweezers
DNA unwinding
Online Access:https://elifesciences.org/articles/54098

Internet

https://elifesciences.org/articles/54098

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