Defining the range of pathogens susceptible to Ifitm3 restriction using a knockout mouse model.

Defining the range of pathogens susceptible to Ifitm3 restriction using a knockout mouse model.

The interferon-inducible transmembrane (IFITM) family of proteins has been shown to restrict a broad range of viruses in vitro and in vivo by halting progress through the late endosomal pathway. Further, single nucleotide polymorphisms (SNPs) in its sequence have been linked with risk of developing...

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Bibliographic Details
Main Authors: Aaron R Everitt, Simon Clare, Jacqueline U McDonald, Leanne Kane, Katherine Harcourt, Malika Ahras, Amar Lall, Christine Hale, Angela Rodgers, Douglas B Young, Ashraful Haque, Oliver Billker, John S Tregoning, Gordon Dougan, Paul Kellam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3836756?pdf=render

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http://europepmc.org/articles/PMC3836756?pdf=render

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