Cerebrospinal Fluid Biomarkers in Relation to MRZ Reaction Status in Primary Progressive Multiple Sclerosis

Cerebrospinal Fluid Biomarkers in Relation to MRZ Reaction Status in Primary Progressive Multiple Sclerosis

The MRZ reaction (MRZR) comprises the three antibody indices (AIs) against measles, rubella, and varicella zoster virus, reflecting an intrathecal polyspecific B cell response highly specific for multiple sclerosis (MS). Thus, MRZR can be used to confirm a diagnosis of primary progressive MS (PPMS)...

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Bibliographic Details
Main Authors: Tilman Robinson, Ahmed Abdelhak, Tanima Bose, Edgar Meinl, Markus Otto, Uwe K. Zettl, Rick Dersch, Hayrettin Tumani, Sebastian Rauer, André Huss
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cells
Subjects:
MRZ reaction (MRZR)
primary progressive multiple sclerosis (PPMS)
B cell-activating factor (BAFF)
chemokine CXC ligand 13 (CXCL-13)
soluble B cell maturation antigen (sBCMA)
soluble transmembrane activator and CAML interactor (sTACI)
Online Access:https://www.mdpi.com/2073-4409/9/12/2543

Internet

https://www.mdpi.com/2073-4409/9/12/2543

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