The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity

The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity

The antihelmintic drug ABZ and its metabolites belong to the chemical family of benzimidazoles (BZM) that act as potent tubulin polymerization inhibitors, suggesting a potential re-direction of BZMs for cancer therapy. Applying UV-Vis spectrometry we here demonstrate ABZ as a DNA intercalator. This...

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Bibliographic Details
Main Authors: Luiza S. E. P. Will Castro, Wietske Pieters, Mir Farshid Alemdehy, Muhammad A. Aslam, Olimpia Alessandra Buoninfante, Jonne A. Raaijmakers, Bas Pilzecker, Paul C. M. van den Berk, Hein te Riele, René H. Medema, Rozangela C. Pedrosa, Heinz Jacobs
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
albendazole
aneuploidy
helminth
spindle poison
loss of heterozygosity (LOH)
cancer predisposition
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.596535/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.596535/full

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