The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production.

The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production.

Dengue virus NS5 is the most highly conserved amongst the viral non-structural proteins and is responsible for capping, methylation and replication of the flavivirus RNA genome. Interactions of NS5 with host proteins also modulate host immune responses. Although replication occurs in the cytoplasm,...

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Bibliographic Details
Main Authors: Moon Y F Tay, Kate Smith, Ivan H W Ng, Kitti W K Chan, Yongqian Zhao, Eng Eong Ooi, Julien Lescar, Dahai Luo, David A Jans, Jade K Forwood, Subhash G Vasudevan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1005886

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https://doi.org/10.1371/journal.ppat.1005886

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