Mapping the Interface of a GPCR Dimer: A Structural Model of the A2A Adenosine and D2 Dopamine Receptor Heteromer

Mapping the Interface of a GPCR Dimer: A Structural Model of the A2A Adenosine and D2 Dopamine Receptor Heteromer

The A2A adenosine (A2AR) and D2 dopamine (D2R) receptors form oligomers in the cell membrane and allosteric interactions across the A2AR–D2R heteromer represent a target for development of drugs against central nervous system disorders. However, understanding of the molecular determinants of A2AR–D2...

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Bibliographic Details
Main Authors: Dasiel O. Borroto-Escuela, David Rodriguez, Wilber Romero-Fernandez, Jon Kapla, Mariama Jaiteh, Anirudh Ranganathan, Tzvetana Lazarova, Kjell Fuxe, Jens Carlsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
G protein-coupled receptor
D2 dopamine receptor
A2A adenosine receptor
heteroreceptor complex
dimerization
dimer interface
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00829/full

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https://www.frontiersin.org/article/10.3389/fphar.2018.00829/full

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