Role of sphingosine 1-phosphate (S1P) and effects of fingolimod, an S1P receptor 1 functional antagonist in lymphocyte circulation and autoimmune diseases

Role of sphingosine 1-phosphate (S1P) and effects of fingolimod, an S1P receptor 1 functional antagonist in lymphocyte circulation and autoimmune diseases

Sphingosine 1-phosphate (S1P), a multi-functional phospholipid mediator, is generated from sphingosine by sphingosine kinases and binds to five known G protein-coupled S1P receptors (S1P1, S1P2, S1P3, S1P4, and S1P5). It is widely accepted that S1P receptor 1 (S1P1) plays an essential role in lympho...

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Bibliographic Details
Main Authors: Kenji Chiba, Yasuhiro Maeda, Noriyasu Seki, Hirotoshi Kataoka, Kunio Sugahara
Format: Article
Language:English
Published: AIMS Press 2014-11-01
Series:AIMS Molecular Science
Subjects:
sphingosine 1-phosphate (S1P)
sphingosine 1-phosphate receptor type 1(S1P1)
fingolimod (FTY720)
lymphocyte egress
experimental autoimmune encephalomyelitis
autoimmune diseases
multiple sclerosis
Online Access:http://www.aimspress.com/article/10.3934/molsci.2014.4.162/fulltext.html

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http://www.aimspress.com/article/10.3934/molsci.2014.4.162/fulltext.html

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