Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease

Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease

Abstract Background New genetic and genomic resources have identified multiple genetic risk factors for late-onset Alzheimer’s disease (LOAD) and characterized this common dementia at the molecular level. Experimental studies in model organisms can validate these associations and elucidate the links...

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Bibliographic Details
Main Authors: Ravi S. Pandey, Leah Graham, Asli Uyar, Christoph Preuss, Gareth R. Howell, Gregory W. Carter
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Animal models
Transcriptomic analysis
Online Access:https://doi.org/10.1186/s13024-019-0351-3

Internet

https://doi.org/10.1186/s13024-019-0351-3

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