The interdependence of mammary-specific super-enhancers and their native promoters facilitates gene activation during pregnancy

Gene regulation: linking enhancers to specific promoters Super-enhancers are regions of DNA that highly activate the expression of specific genes. Research led by H.K.L. and L.H. at the National Institutes of Health, USA, now demonstrate that a super-enhancer is much more effective when operating in...

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Bibliographic Details
Main Authors: Xianke Zeng, Hye Kyung Lee, Chaochen Wang, Precious Achikeh, Chengyu Liu, Lothar Hennighausen
Format: Article
Language:English
Published: Nature Publishing Group 2020-04-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-020-0425-x