A TNF-regulated recombinatorial macrophage immune receptor implicated in granuloma formation in tuberculosis.

A TNF-regulated recombinatorial macrophage immune receptor implicated in granuloma formation in tuberculosis.

Macrophages play a central role in host defense against mycobacterial infection and anti- TNF therapy is associated with granuloma disorganization and reactivation of tuberculosis in humans. Here, we provide evidence for the presence of a T cell receptor (TCR) αβ based recombinatorial immune recepto...

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Bibliographic Details
Main Authors: Alexander W Beham, Kerstin Puellmann, Rebecca Laird, Tina Fuchs, Roswita Streich, Caroline Breysach, Dirk Raddatz, Septimia Oniga, Teresa Peccerella, Peter Findeisen, Julia Kzhyshkowska, Alexei Gratchev, Stefan Schweyer, Bernadette Saunders, Johannes T Wessels, Wiebke Möbius, Joseph Keane, Heinz Becker, Arnold Ganser, Michael Neumaier, Wolfgang E Kaminski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-11-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3219713?pdf=render

Internet

http://europepmc.org/articles/PMC3219713?pdf=render

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