Selection of Small Molecules that Bind to and Activate the Insulin Receptor from a DNA-Encoded Library of Natural Products

Selection of Small Molecules that Bind to and Activate the Insulin Receptor from a DNA-Encoded Library of Natural Products

Summary: Although insulin is a life-saving medicine, administration by daily injection remains problematic. Our goal was to exploit the power of DNA-encoded libraries to identify molecules with insulin-like activity but with the potential to be developed as oral drugs. Our strategy involved using a...

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Bibliographic Details
Main Authors: Jia Xie, Shuyue Wang, Peixiang Ma, Fei Ma, Jie Li, Wei Wang, Fengping Lu, Huan Xiong, Yuang Gu, Shuning Zhang, Hongtao Xu, Guang Yang, Richard A. Lerner
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:iScience
Subjects:
Natural Product Chemistry
Biochemistry
Biotechnology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220303825

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http://www.sciencedirect.com/science/article/pii/S2589004220303825

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