Identification of Novel 1,3,5-Triphenylbenzene Derivative Compounds as Inhibitors of Hen Lysozyme Amyloid Fibril Formation

Identification of Novel 1,3,5-Triphenylbenzene Derivative Compounds as Inhibitors of Hen Lysozyme Amyloid Fibril Formation

Deposition of soluble proteins as insoluble amyloid fibrils is associated with a number of pathological states. There is a growing interest in the identification of small molecules that can prevent proteins from undergoing amyloid fibril formation. In the present study, a series of small aromatic co...

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Bibliographic Details
Main Authors: Hassan Ramshini, Reza Tayebee, Alessandra Bigi, Francesco Bemporad, Cristina Cecchi, Fabrizio Chiti
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:International Journal of Molecular Sciences
Subjects:
protein misfolding
hewl amyloid aggregation
drug discovery
small aromatic compounds
amyloid inhibitors
triphenylbenzene
Online Access:https://www.mdpi.com/1422-0067/20/22/5558

Internet

https://www.mdpi.com/1422-0067/20/22/5558

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