Radiation synergizes with antitumor activity of CD13-targeted tissue factor in a HT1080 xenograft model of human soft tissue sarcoma.

Radiation synergizes with antitumor activity of CD13-targeted tissue factor in a HT1080 xenograft model of human soft tissue sarcoma.

BACKGROUND:Truncated tissue factor (tTF) retargeted by NGR-peptides to aminopeptidase N (CD13) in tumor vasculature is effective in experimental tumor therapy. tTF-NGR induces tumor growth inhibition in a variety of human tumor xenografts of different histology. To improve on the therapeutic efficac...

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Bibliographic Details
Main Authors: Caroline Brand, Burkhard Greve, Tobias Bölling, Hans T Eich, Normann Willich, Saliha Harrach, Heike Hintelmann, Georg Lenz, Rolf M Mesters, Torsten Kessler, Christoph Schliemann, Wolfgang E Berdel, Christian Schwöppe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0229271

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https://doi.org/10.1371/journal.pone.0229271

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