Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration.

The mammalian protein kinase N (PKN) family of Serine/Threonine kinases comprises three isoforms, which are targets for Rho family GTPases. Small GTPases are major regulators of the cellular cytoskeleton, generating interest in the role(s) of specific PKN isoforms in processes such as cell migration...

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Bibliographic Details
Main Authors: Sylvie Lachmann, Amy Jevons, Manu De Rycker, Adele Casamassima, Simone Radtke, Alejandra Collazos, Peter J Parker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3130767?pdf=render