Replication stress induces micronuclei comprising of aggregated DNA double-strand breaks.

Replication stress induces micronuclei comprising of aggregated DNA double-strand breaks.

<h4>Background</h4>Micronuclei (MN) in mammalian cells serve as a reliable biomarker of genomic instability and genotoxic exposure. Elevation of MN is commonly observed in cells bearing intrinsic genomic instability and in normal cells exposed to genotoxic agents. DNA double-strand break...

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Bibliographic Details
Main Authors: Bing Xu, Zhaoliang Sun, Zhaojian Liu, Haiyang Guo, Qiao Liu, Haiyan Jiang, Yongxin Zou, Yaoqin Gong, Jay A Tischfield, Changshun Shao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21525980/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21525980/?tool=EBI

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