The switch between acute and persistent paramyxovirus infection caused by single amino acid substitutions in the RNA polymerase P subunit.

The switch between acute and persistent paramyxovirus infection caused by single amino acid substitutions in the RNA polymerase P subunit.

Paramyxoviruses can establish persistent infections both in vitro and in vivo, some of which lead to chronic disease. However, little is known about the molecular events that contribute to the establishment of persistent infections by RNA viruses. Using parainfluenza virus type 5 (PIV5) as a model w...

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Bibliographic Details
Main Authors: Dan F Young, Elizabeth B Wignall-Fleming, David C Busse, Matthew J Pickin, Jack Hankinson, Elizabeth M Randall, Amy Tavendale, Andrew J Davison, Douglas Lamont, John S Tregoning, Steve Goodbourn, Richard E Randall
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007561

Internet

https://doi.org/10.1371/journal.ppat.1007561

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