A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Breast cancer risk for BRCA1/BRCA2 mutation carriers varies depending on other genetic factors. Here, the authors perform a case-only genome-wide association study and highlight novel loci associated with breast cancer risk for BRCA1/BRCA2 mutation carriers.

Bibliographic Details
Main Authors:	Juliette Coignard, Michael Lush, Jonathan Beesley, Tracy A. O’Mara, Joe Dennis, Jonathan P. Tyrer, Daniel R. Barnes, Lesley McGuffog, Goska Leslie, Manjeet K. Bolla, Muriel A. Adank, Simona Agata, Thomas Ahearn, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Norbert Arnold, Kristan J. Aronson, Banu K. Arun, Annelie Augustinsson, Jacopo Azzollini, Daniel Barrowdale, Caroline Baynes, Heko Becher, Marina Bermisheva, Leslie Bernstein, Katarzyna Białkowska, Carl Blomqvist, Stig E. Bojesen, Bernardo Bonanni, Ake Borg, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Saundra S. Buys, Trinidad Caldés, Maria A. Caligo, Daniele Campa, Brian D. Carter, Jose E. Castelao, Jenny Chang-Claude, Stephen J. Chanock, Wendy K. Chung, Kathleen B. M. Claes, Christine L. Clarke, GEMO Study Collaborators, EMBRACE Collaborators, J. Margriet Collée, Don M. Conroy, Kamila Czene, Mary B. Daly, Peter Devilee, Orland Diez, Yuan Chun Ding, Susan M. Domchek, Thilo Dörk, Isabel dos-Santos-Silva, Alison M. Dunning, Miriam Dwek, Diana M. Eccles, A. Heather Eliassen, Christoph Engel, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Henrik Flyger, Florentia Fostira, Eitan Friedman, Lin Fritschi, Debra Frost, Manuela Gago-Dominguez, Susan M. Gapstur, Judy Garber, Vanesa Garcia-Barberan, Montserrat García-Closas, José A. García-Sáenz, Mia M. Gaudet, Simon A. Gayther, Andrea Gehrig, Vassilios Georgoulias, Graham G. Giles, Andrew K. Godwin, Mark S. Goldberg, David E. Goldgar, Anna González-Neira, Mark H. Greene, Pascal Guénel, Lothar Haeberle, Eric Hahnen, Christopher A. Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Patricia A. Harrington, Steven N. Hart, Wei He, Frans B. L. Hogervorst, Antoinette Hollestelle, John L. Hopper, Darling J. Horcasitas, Peter J. Hulick, David J. Hunter, Evgeny N. Imyanitov, KConFab Investigators, HEBON Investigators, ABCTB Investigators, Agnes Jager, Anna Jakubowska, Paul A. James, Uffe Birk Jensen, Esther M. John, Michael E. Jones, Rudolf Kaaks, Pooja Middha Kapoor, Beth Y. Karlan, Renske Keeman, Elza Khusnutdinova, Johanna I. Kiiski, Yon-Dschun Ko, Veli-Matti Kosma, Peter Kraft, Allison W. Kurian, Yael Laitman, Diether Lambrechts, Loic Le Marchand, Jenny Lester, Fabienne Lesueur, Tricia Lindstrom, Adria Lopez-Fernández, Jennifer T. Loud, Craig Luccarini, Arto Mannermaa, Siranoush Manoukian, Sara Margolin, John W. M. Martens, Noura Mebirouk, Alfons Meindl, Austin Miller, Roger L. Milne, Marco Montagna, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Finn C. Nielsen, Katie M. O’Brien, Olufunmilayo I. Olopade, Janet E. Olson, Håkan Olsson, Ana Osorio, Laura Ottini, Tjoung-Won Park-Simon, Michael T. Parsons, Inge Sokilde Pedersen, Beth Peshkin, Paolo Peterlongo, Julian Peto, Paul D. P. Pharoah, Kelly-Anne Phillips, Eric C. Polley, Bruce Poppe, Nadege Presneau, Miquel Angel Pujana, Kevin Punie, Paolo Radice, Johanna Rantala, Muhammad U. Rashid, Gad Rennert, Hedy S. Rennert, Mark Robson, Atocha Romero, Maria Rossing, Emmanouil Saloustros, Dale P. Sandler, Regina Santella, Maren T. Scheuner, Marjanka K. Schmidt, Gunnar Schmidt, Christopher Scott, Priyanka Sharma, Penny Soucy, Melissa C. Southey, John J. Spinelli, Zoe Steinsnyder, Jennifer Stone, Dominique Stoppa-Lyonnet, Anthony Swerdlow, Rulla M. Tamimi, William J. Tapper, Jack A. Taylor, Mary Beth Terry, Alex Teulé, Darcy L. Thull, Marc Tischkowitz, Amanda E. Toland, Diana Torres, Alison H. Trainer, Thérèse Truong, Nadine Tung, Celine M. Vachon, Ana Vega, Joseph Vijai, Qin Wang, Barbara Wappenschmidt, Clarice R. Weinberg, Jeffrey N. Weitzel, Camilla Wendt, Alicja Wolk, Siddhartha Yadav, Xiaohong R. Yang, Drakoulis Yannoukakos, Wei Zheng, Argyrios Ziogas, Kristin K. Zorn, Sue K. Park, Mads Thomassen, Kenneth Offit, Rita K. Schmutzler, Fergus J. Couch, Jacques Simard, Georgia Chenevix-Trench, Douglas F. Easton, Nadine Andrieu, Antonis C. Antoniou
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-20496-3

id	doaj-a26ed9dc06884844b6173e2662499c7f
record_format	Article
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Juliette Coignard Michael Lush Jonathan Beesley Tracy A. O’Mara Joe Dennis Jonathan P. Tyrer Daniel R. Barnes Lesley McGuffog Goska Leslie Manjeet K. Bolla Muriel A. Adank Simona Agata Thomas Ahearn Kristiina Aittomäki Irene L. Andrulis Hoda Anton-Culver Volker Arndt Norbert Arnold Kristan J. Aronson Banu K. Arun Annelie Augustinsson Jacopo Azzollini Daniel Barrowdale Caroline Baynes Heko Becher Marina Bermisheva Leslie Bernstein Katarzyna Białkowska Carl Blomqvist Stig E. Bojesen Bernardo Bonanni Ake Borg Hiltrud Brauch Hermann Brenner Barbara Burwinkel Saundra S. Buys Trinidad Caldés Maria A. Caligo Daniele Campa Brian D. Carter Jose E. Castelao Jenny Chang-Claude Stephen J. Chanock Wendy K. Chung Kathleen B. M. Claes Christine L. Clarke GEMO Study Collaborators EMBRACE Collaborators J. Margriet Collée Don M. Conroy Kamila Czene Mary B. Daly Peter Devilee Orland Diez Yuan Chun Ding Susan M. Domchek Thilo Dörk Isabel dos-Santos-Silva Alison M. Dunning Miriam Dwek Diana M. Eccles A. Heather Eliassen Christoph Engel Mikael Eriksson D. Gareth Evans Peter A. Fasching Henrik Flyger Florentia Fostira Eitan Friedman Lin Fritschi Debra Frost Manuela Gago-Dominguez Susan M. Gapstur Judy Garber Vanesa Garcia-Barberan Montserrat García-Closas José A. García-Sáenz Mia M. Gaudet Simon A. Gayther Andrea Gehrig Vassilios Georgoulias Graham G. Giles Andrew K. Godwin Mark S. Goldberg David E. Goldgar Anna González-Neira Mark H. Greene Pascal Guénel Lothar Haeberle Eric Hahnen Christopher A. Haiman Niclas Håkansson Per Hall Ute Hamann Patricia A. Harrington Steven N. Hart Wei He Frans B. L. Hogervorst Antoinette Hollestelle John L. Hopper Darling J. Horcasitas Peter J. Hulick David J. Hunter Evgeny N. Imyanitov KConFab Investigators HEBON Investigators ABCTB Investigators Agnes Jager Anna Jakubowska Paul A. James Uffe Birk Jensen Esther M. John Michael E. Jones Rudolf Kaaks Pooja Middha Kapoor Beth Y. Karlan Renske Keeman Elza Khusnutdinova Johanna I. Kiiski Yon-Dschun Ko Veli-Matti Kosma Peter Kraft Allison W. Kurian Yael Laitman Diether Lambrechts Loic Le Marchand Jenny Lester Fabienne Lesueur Tricia Lindstrom Adria Lopez-Fernández Jennifer T. Loud Craig Luccarini Arto Mannermaa Siranoush Manoukian Sara Margolin John W. M. Martens Noura Mebirouk Alfons Meindl Austin Miller Roger L. Milne Marco Montagna Katherine L. Nathanson Susan L. Neuhausen Heli Nevanlinna Finn C. Nielsen Katie M. O’Brien Olufunmilayo I. Olopade Janet E. Olson Håkan Olsson Ana Osorio Laura Ottini Tjoung-Won Park-Simon Michael T. Parsons Inge Sokilde Pedersen Beth Peshkin Paolo Peterlongo Julian Peto Paul D. P. Pharoah Kelly-Anne Phillips Eric C. Polley Bruce Poppe Nadege Presneau Miquel Angel Pujana Kevin Punie Paolo Radice Johanna Rantala Muhammad U. Rashid Gad Rennert Hedy S. Rennert Mark Robson Atocha Romero Maria Rossing Emmanouil Saloustros Dale P. Sandler Regina Santella Maren T. Scheuner Marjanka K. Schmidt Gunnar Schmidt Christopher Scott Priyanka Sharma Penny Soucy Melissa C. Southey John J. Spinelli Zoe Steinsnyder Jennifer Stone Dominique Stoppa-Lyonnet Anthony Swerdlow Rulla M. Tamimi William J. Tapper Jack A. Taylor Mary Beth Terry Alex Teulé Darcy L. Thull Marc Tischkowitz Amanda E. Toland Diana Torres Alison H. Trainer Thérèse Truong Nadine Tung Celine M. Vachon Ana Vega Joseph Vijai Qin Wang Barbara Wappenschmidt Clarice R. Weinberg Jeffrey N. Weitzel Camilla Wendt Alicja Wolk Siddhartha Yadav Xiaohong R. Yang Drakoulis Yannoukakos Wei Zheng Argyrios Ziogas Kristin K. Zorn Sue K. Park Mads Thomassen Kenneth Offit Rita K. Schmutzler Fergus J. Couch Jacques Simard Georgia Chenevix-Trench Douglas F. Easton Nadine Andrieu Antonis C. Antoniou
spellingShingle	Juliette Coignard Michael Lush Jonathan Beesley Tracy A. O’Mara Joe Dennis Jonathan P. Tyrer Daniel R. Barnes Lesley McGuffog Goska Leslie Manjeet K. Bolla Muriel A. Adank Simona Agata Thomas Ahearn Kristiina Aittomäki Irene L. Andrulis Hoda Anton-Culver Volker Arndt Norbert Arnold Kristan J. Aronson Banu K. Arun Annelie Augustinsson Jacopo Azzollini Daniel Barrowdale Caroline Baynes Heko Becher Marina Bermisheva Leslie Bernstein Katarzyna Białkowska Carl Blomqvist Stig E. Bojesen Bernardo Bonanni Ake Borg Hiltrud Brauch Hermann Brenner Barbara Burwinkel Saundra S. Buys Trinidad Caldés Maria A. Caligo Daniele Campa Brian D. Carter Jose E. Castelao Jenny Chang-Claude Stephen J. Chanock Wendy K. Chung Kathleen B. M. Claes Christine L. Clarke GEMO Study Collaborators EMBRACE Collaborators J. Margriet Collée Don M. Conroy Kamila Czene Mary B. Daly Peter Devilee Orland Diez Yuan Chun Ding Susan M. Domchek Thilo Dörk Isabel dos-Santos-Silva Alison M. Dunning Miriam Dwek Diana M. Eccles A. Heather Eliassen Christoph Engel Mikael Eriksson D. Gareth Evans Peter A. Fasching Henrik Flyger Florentia Fostira Eitan Friedman Lin Fritschi Debra Frost Manuela Gago-Dominguez Susan M. Gapstur Judy Garber Vanesa Garcia-Barberan Montserrat García-Closas José A. García-Sáenz Mia M. Gaudet Simon A. Gayther Andrea Gehrig Vassilios Georgoulias Graham G. Giles Andrew K. Godwin Mark S. Goldberg David E. Goldgar Anna González-Neira Mark H. Greene Pascal Guénel Lothar Haeberle Eric Hahnen Christopher A. Haiman Niclas Håkansson Per Hall Ute Hamann Patricia A. Harrington Steven N. Hart Wei He Frans B. L. Hogervorst Antoinette Hollestelle John L. Hopper Darling J. Horcasitas Peter J. Hulick David J. Hunter Evgeny N. Imyanitov KConFab Investigators HEBON Investigators ABCTB Investigators Agnes Jager Anna Jakubowska Paul A. James Uffe Birk Jensen Esther M. John Michael E. Jones Rudolf Kaaks Pooja Middha Kapoor Beth Y. Karlan Renske Keeman Elza Khusnutdinova Johanna I. Kiiski Yon-Dschun Ko Veli-Matti Kosma Peter Kraft Allison W. Kurian Yael Laitman Diether Lambrechts Loic Le Marchand Jenny Lester Fabienne Lesueur Tricia Lindstrom Adria Lopez-Fernández Jennifer T. Loud Craig Luccarini Arto Mannermaa Siranoush Manoukian Sara Margolin John W. M. Martens Noura Mebirouk Alfons Meindl Austin Miller Roger L. Milne Marco Montagna Katherine L. Nathanson Susan L. Neuhausen Heli Nevanlinna Finn C. Nielsen Katie M. O’Brien Olufunmilayo I. Olopade Janet E. Olson Håkan Olsson Ana Osorio Laura Ottini Tjoung-Won Park-Simon Michael T. Parsons Inge Sokilde Pedersen Beth Peshkin Paolo Peterlongo Julian Peto Paul D. P. Pharoah Kelly-Anne Phillips Eric C. Polley Bruce Poppe Nadege Presneau Miquel Angel Pujana Kevin Punie Paolo Radice Johanna Rantala Muhammad U. Rashid Gad Rennert Hedy S. Rennert Mark Robson Atocha Romero Maria Rossing Emmanouil Saloustros Dale P. Sandler Regina Santella Maren T. Scheuner Marjanka K. Schmidt Gunnar Schmidt Christopher Scott Priyanka Sharma Penny Soucy Melissa C. Southey John J. Spinelli Zoe Steinsnyder Jennifer Stone Dominique Stoppa-Lyonnet Anthony Swerdlow Rulla M. Tamimi William J. Tapper Jack A. Taylor Mary Beth Terry Alex Teulé Darcy L. Thull Marc Tischkowitz Amanda E. Toland Diana Torres Alison H. Trainer Thérèse Truong Nadine Tung Celine M. Vachon Ana Vega Joseph Vijai Qin Wang Barbara Wappenschmidt Clarice R. Weinberg Jeffrey N. Weitzel Camilla Wendt Alicja Wolk Siddhartha Yadav Xiaohong R. Yang Drakoulis Yannoukakos Wei Zheng Argyrios Ziogas Kristin K. Zorn Sue K. Park Mads Thomassen Kenneth Offit Rita K. Schmutzler Fergus J. Couch Jacques Simard Georgia Chenevix-Trench Douglas F. Easton Nadine Andrieu Antonis C. Antoniou A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers Nature Communications
author_facet	Juliette Coignard Michael Lush Jonathan Beesley Tracy A. O’Mara Joe Dennis Jonathan P. Tyrer Daniel R. Barnes Lesley McGuffog Goska Leslie Manjeet K. Bolla Muriel A. Adank Simona Agata Thomas Ahearn Kristiina Aittomäki Irene L. Andrulis Hoda Anton-Culver Volker Arndt Norbert Arnold Kristan J. Aronson Banu K. Arun Annelie Augustinsson Jacopo Azzollini Daniel Barrowdale Caroline Baynes Heko Becher Marina Bermisheva Leslie Bernstein Katarzyna Białkowska Carl Blomqvist Stig E. Bojesen Bernardo Bonanni Ake Borg Hiltrud Brauch Hermann Brenner Barbara Burwinkel Saundra S. Buys Trinidad Caldés Maria A. Caligo Daniele Campa Brian D. Carter Jose E. Castelao Jenny Chang-Claude Stephen J. Chanock Wendy K. Chung Kathleen B. M. Claes Christine L. Clarke GEMO Study Collaborators EMBRACE Collaborators J. Margriet Collée Don M. Conroy Kamila Czene Mary B. Daly Peter Devilee Orland Diez Yuan Chun Ding Susan M. Domchek Thilo Dörk Isabel dos-Santos-Silva Alison M. Dunning Miriam Dwek Diana M. Eccles A. Heather Eliassen Christoph Engel Mikael Eriksson D. Gareth Evans Peter A. Fasching Henrik Flyger Florentia Fostira Eitan Friedman Lin Fritschi Debra Frost Manuela Gago-Dominguez Susan M. Gapstur Judy Garber Vanesa Garcia-Barberan Montserrat García-Closas José A. García-Sáenz Mia M. Gaudet Simon A. Gayther Andrea Gehrig Vassilios Georgoulias Graham G. Giles Andrew K. Godwin Mark S. Goldberg David E. Goldgar Anna González-Neira Mark H. Greene Pascal Guénel Lothar Haeberle Eric Hahnen Christopher A. Haiman Niclas Håkansson Per Hall Ute Hamann Patricia A. Harrington Steven N. Hart Wei He Frans B. L. Hogervorst Antoinette Hollestelle John L. Hopper Darling J. Horcasitas Peter J. Hulick David J. Hunter Evgeny N. Imyanitov KConFab Investigators HEBON Investigators ABCTB Investigators Agnes Jager Anna Jakubowska Paul A. James Uffe Birk Jensen Esther M. John Michael E. Jones Rudolf Kaaks Pooja Middha Kapoor Beth Y. Karlan Renske Keeman Elza Khusnutdinova Johanna I. Kiiski Yon-Dschun Ko Veli-Matti Kosma Peter Kraft Allison W. Kurian Yael Laitman Diether Lambrechts Loic Le Marchand Jenny Lester Fabienne Lesueur Tricia Lindstrom Adria Lopez-Fernández Jennifer T. Loud Craig Luccarini Arto Mannermaa Siranoush Manoukian Sara Margolin John W. M. Martens Noura Mebirouk Alfons Meindl Austin Miller Roger L. Milne Marco Montagna Katherine L. Nathanson Susan L. Neuhausen Heli Nevanlinna Finn C. Nielsen Katie M. O’Brien Olufunmilayo I. Olopade Janet E. Olson Håkan Olsson Ana Osorio Laura Ottini Tjoung-Won Park-Simon Michael T. Parsons Inge Sokilde Pedersen Beth Peshkin Paolo Peterlongo Julian Peto Paul D. P. Pharoah Kelly-Anne Phillips Eric C. Polley Bruce Poppe Nadege Presneau Miquel Angel Pujana Kevin Punie Paolo Radice Johanna Rantala Muhammad U. Rashid Gad Rennert Hedy S. Rennert Mark Robson Atocha Romero Maria Rossing Emmanouil Saloustros Dale P. Sandler Regina Santella Maren T. Scheuner Marjanka K. Schmidt Gunnar Schmidt Christopher Scott Priyanka Sharma Penny Soucy Melissa C. Southey John J. Spinelli Zoe Steinsnyder Jennifer Stone Dominique Stoppa-Lyonnet Anthony Swerdlow Rulla M. Tamimi William J. Tapper Jack A. Taylor Mary Beth Terry Alex Teulé Darcy L. Thull Marc Tischkowitz Amanda E. Toland Diana Torres Alison H. Trainer Thérèse Truong Nadine Tung Celine M. Vachon Ana Vega Joseph Vijai Qin Wang Barbara Wappenschmidt Clarice R. Weinberg Jeffrey N. Weitzel Camilla Wendt Alicja Wolk Siddhartha Yadav Xiaohong R. Yang Drakoulis Yannoukakos Wei Zheng Argyrios Ziogas Kristin K. Zorn Sue K. Park Mads Thomassen Kenneth Offit Rita K. Schmutzler Fergus J. Couch Jacques Simard Georgia Chenevix-Trench Douglas F. Easton Nadine Andrieu Antonis C. Antoniou
author_sort	Juliette Coignard
title	A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers
title_short	A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers
title_full	A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers
title_fullStr	A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers
title_full_unstemmed	A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers
title_sort	case-only study to identify genetic modifiers of breast cancer risk for brca1/brca2 mutation carriers
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-02-01
description	Breast cancer risk for BRCA1/BRCA2 mutation carriers varies depending on other genetic factors. Here, the authors perform a case-only genome-wide association study and highlight novel loci associated with breast cancer risk for BRCA1/BRCA2 mutation carriers.
url	https://doi.org/10.1038/s41467-020-20496-3
work_keys_str_mv	AT juliettecoignard acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT michaellush acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT jonathanbeesley acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT tracyaomara acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT joedennis acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT jonathanptyrer acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT danielrbarnes acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT lesleymcguffog acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT goskaleslie acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT manjeetkbolla acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT murielaadank acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT simonaagata acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT thomasahearn acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT kristiinaaittomaki acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT irenelandrulis acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT hodaantonculver acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT volkerarndt acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT norbertarnold acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT kristanjaronson acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT banukarun acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT annelieaugustinsson acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT jacopoazzollini acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT danielbarrowdale acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT carolinebaynes acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT hekobecher acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT marinabermisheva acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT lesliebernstein acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT katarzynabiałkowska acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT carlblomqvist acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT stigebojesen acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT bernardobonanni acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT akeborg acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT hiltrudbrauch acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT hermannbrenner acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT barbaraburwinkel acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT saundrasbuys acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT trinidadcaldes acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT mariaacaligo acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT danielecampa acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT briandcarter acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT joseecastelao acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT jennychangclaude acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT stephenjchanock acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT wendykchung acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT kathleenbmclaes acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT christinelclarke acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT gemostudycollaborators acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT embracecollaborators acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT jmargrietcollee acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT donmconroy acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT kamilaczene acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT marybdaly acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT peterdevilee acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT orlanddiez acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT yuanchunding acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT susanmdomchek acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT thilodork acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT isabeldossantossilva acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT alisonmdunning acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT miriamdwek acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT dianameccles acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT aheathereliassen acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT christophengel acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT mikaeleriksson acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT dgarethevans acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT peterafasching acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT henrikflyger acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT florentiafostira acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT eitanfriedman acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT linfritschi acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT debrafrost acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT manuelagagodominguez acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT susanmgapstur acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT judygarber acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT vanesagarciabarberan acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT montserratgarciaclosas acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT joseagarciasaenz acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT miamgaudet acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT simonagayther acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT andreagehrig acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT vassiliosgeorgoulias acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT grahamggiles acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT andrewkgodwin acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT marksgoldberg acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT davidegoldgar acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT annagonzalezneira acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT markhgreene acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT pascalguenel acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT lotharhaeberle acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT erichahnen acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT christopherahaiman acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT niclashakansson acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT perhall acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT utehamann acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT patriciaaharrington acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT stevennhart acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT weihe acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT fransblhogervorst acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT antoinettehollestelle acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT johnlhopper acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT darlingjhorcasitas acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT peterjhulick acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT davidjhunter acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT evgenynimyanitov acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT kconfabinvestigators acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT heboninvestigators acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT abctbinvestigators acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT agnesjager acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT annajakubowska acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT paulajames acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT uffebirkjensen acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT esthermjohn acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT michaelejones acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT rudolfkaaks acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT poojamiddhakapoor acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT bethykarlan acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT renskekeeman acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT elzakhusnutdinova acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT johannaikiiski acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT yondschunko acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT velimattikosma acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT peterkraft acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT allisonwkurian acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT yaellaitman acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT dietherlambrechts acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT loiclemarchand acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT jennylester acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT fabiennelesueur acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT tricialindstrom acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT adrialopezfernandez acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT jennifertloud acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT craigluccarini acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT artomannermaa acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT siranoushmanoukian acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT saramargolin acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT johnwmmartens acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT nouramebirouk acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT alfonsmeindl acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT austinmiller acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT rogerlmilne acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT marcomontagna acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT katherinelnathanson acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT susanlneuhausen acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT helinevanlinna acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT finncnielsen acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT katiemobrien acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT olufunmilayoiolopade acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT janeteolson acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT hakanolsson acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT anaosorio acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT lauraottini acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT tjoungwonparksimon acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT michaeltparsons acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT ingesokildepedersen acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT bethpeshkin acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT paolopeterlongo acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT julianpeto acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT pauldppharoah acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT kellyannephillips acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT ericcpolley acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT brucepoppe acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT nadegepresneau acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT miquelangelpujana acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT kevinpunie acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT paoloradice acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT johannarantala acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT muhammadurashid acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT gadrennert acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT hedysrennert acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT markrobson acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT atocharomero acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT mariarossing acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT emmanouilsaloustros acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT dalepsandler acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT reginasantella acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT marentscheuner acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT marjankakschmidt acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT gunnarschmidt acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT christopherscott acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT priyankasharma acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT pennysoucy acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT melissacsouthey acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT johnjspinelli acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT zoesteinsnyder acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT jenniferstone acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT dominiquestoppalyonnet acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT anthonyswerdlow acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT rullamtamimi acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT williamjtapper acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT jackataylor acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT marybethterry acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT alexteule acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT darcylthull acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT marctischkowitz acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT amandaetoland acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT dianatorres acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT alisonhtrainer acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT theresetruong acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT nadinetung acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT celinemvachon acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT anavega acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT josephvijai acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT qinwang acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT barbarawappenschmidt acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT claricerweinberg acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT jeffreynweitzel acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT camillawendt acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT alicjawolk acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT siddharthayadav acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT xiaohongryang acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT drakoulisyannoukakos acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT weizheng acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT argyriosziogas acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT kristinkzorn acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT suekpark acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT madsthomassen acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT kennethoffit acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT ritakschmutzler acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT fergusjcouch acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT jacquessimard acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT georgiachenevixtrench acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT douglasfeaston acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT nadineandrieu acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT antoniscantoniou acaseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT juliettecoignard caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT michaellush caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT jonathanbeesley caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT tracyaomara caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT joedennis caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT jonathanptyrer caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT danielrbarnes caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT lesleymcguffog caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT goskaleslie caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT manjeetkbolla caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT murielaadank caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT simonaagata caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT thomasahearn caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT kristiinaaittomaki caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT irenelandrulis caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT hodaantonculver caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT volkerarndt caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT norbertarnold caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT kristanjaronson caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT banukarun caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT annelieaugustinsson caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT jacopoazzollini caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT danielbarrowdale caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT carolinebaynes caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT hekobecher caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT marinabermisheva caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT lesliebernstein caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT katarzynabiałkowska caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT carlblomqvist caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT stigebojesen caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT bernardobonanni caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT akeborg caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT hiltrudbrauch caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT hermannbrenner caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT barbaraburwinkel caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT saundrasbuys caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT trinidadcaldes caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT mariaacaligo caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT danielecampa caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT briandcarter caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT joseecastelao caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT jennychangclaude caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT stephenjchanock caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT wendykchung caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT kathleenbmclaes caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT christinelclarke caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT gemostudycollaborators caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT embracecollaborators caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT jmargrietcollee caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT donmconroy caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT kamilaczene caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT marybdaly caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT peterdevilee caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT orlanddiez caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT yuanchunding caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT susanmdomchek caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT thilodork caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT isabeldossantossilva caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT alisonmdunning caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT miriamdwek caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT dianameccles caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT aheathereliassen caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT christophengel caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT mikaeleriksson caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT dgarethevans caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT peterafasching caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT henrikflyger caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT florentiafostira caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT eitanfriedman caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT linfritschi caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT debrafrost caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT manuelagagodominguez caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT susanmgapstur caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT judygarber caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT vanesagarciabarberan caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT montserratgarciaclosas caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT joseagarciasaenz caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT miamgaudet caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT simonagayther caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT andreagehrig caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT vassiliosgeorgoulias caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT grahamggiles caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT andrewkgodwin caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT marksgoldberg caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT davidegoldgar caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT annagonzalezneira caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT markhgreene caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT pascalguenel caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT lotharhaeberle caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT erichahnen caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT christopherahaiman caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT niclashakansson caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT perhall caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT utehamann caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT patriciaaharrington caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT stevennhart caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT weihe caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT fransblhogervorst caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT antoinettehollestelle caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT johnlhopper caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT darlingjhorcasitas caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT peterjhulick caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT davidjhunter caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT evgenynimyanitov caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT kconfabinvestigators caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT heboninvestigators caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT abctbinvestigators caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT agnesjager caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT annajakubowska caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT paulajames caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT uffebirkjensen caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT esthermjohn caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT michaelejones caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT rudolfkaaks caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT poojamiddhakapoor caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT bethykarlan caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT renskekeeman caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT elzakhusnutdinova caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT johannaikiiski caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT yondschunko caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT velimattikosma caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT peterkraft caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT allisonwkurian caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT yaellaitman caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT dietherlambrechts caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT loiclemarchand caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT jennylester caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT fabiennelesueur caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT tricialindstrom caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT adrialopezfernandez caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT jennifertloud caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT craigluccarini caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT artomannermaa caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT siranoushmanoukian caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT saramargolin caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT johnwmmartens caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT nouramebirouk caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT alfonsmeindl caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT austinmiller caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT rogerlmilne caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT marcomontagna caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT katherinelnathanson caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT susanlneuhausen caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT helinevanlinna caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT finncnielsen caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT katiemobrien caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT olufunmilayoiolopade caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT janeteolson caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT hakanolsson caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT anaosorio caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT lauraottini caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT tjoungwonparksimon caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT michaeltparsons caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT ingesokildepedersen caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT bethpeshkin caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT paolopeterlongo caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT julianpeto caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT pauldppharoah caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT kellyannephillips caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT ericcpolley caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT brucepoppe caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT nadegepresneau caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT miquelangelpujana caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT kevinpunie caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT paoloradice caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT johannarantala caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT muhammadurashid caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT gadrennert caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT hedysrennert caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT markrobson caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT atocharomero caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT mariarossing caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT emmanouilsaloustros caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT dalepsandler caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT reginasantella caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT marentscheuner caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT marjankakschmidt caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT gunnarschmidt caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT christopherscott caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT priyankasharma caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT pennysoucy caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT melissacsouthey caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT johnjspinelli caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT zoesteinsnyder caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT jenniferstone caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT dominiquestoppalyonnet caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT anthonyswerdlow caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT rullamtamimi caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT williamjtapper caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT jackataylor caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT marybethterry caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT alexteule caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT darcylthull caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT marctischkowitz caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT amandaetoland caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT dianatorres caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT alisonhtrainer caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT theresetruong caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT nadinetung caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT celinemvachon caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT anavega caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT josephvijai caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT qinwang caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT barbarawappenschmidt caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT claricerweinberg caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT jeffreynweitzel caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT camillawendt caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT alicjawolk caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT siddharthayadav caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT xiaohongryang caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT drakoulisyannoukakos caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT weizheng caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT argyriosziogas caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT kristinkzorn caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT suekpark caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT madsthomassen caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT kennethoffit caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT ritakschmutzler caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT fergusjcouch caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT jacquessimard caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT georgiachenevixtrench caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT douglasfeaston caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT nadineandrieu caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers AT antoniscantoniou caseonlystudytoidentifygeneticmodifiersofbreastcancerriskforbrca1brca2mutationcarriers
_version_	1724258416690462720
spelling	doaj-a26ed9dc06884844b6173e2662499c7f2021-02-21T12:12:42ZengNature Publishing GroupNature Communications2041-17232021-02-0112112210.1038/s41467-020-20496-3A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriersJuliette Coignard0Michael Lush1Jonathan Beesley2Tracy A. O’Mara3Joe Dennis4Jonathan P. Tyrer5Daniel R. Barnes6Lesley McGuffog7Goska Leslie8Manjeet K. Bolla9Muriel A. Adank10Simona Agata11Thomas Ahearn12Kristiina Aittomäki13Irene L. Andrulis14Hoda Anton-Culver15Volker Arndt16Norbert Arnold17Kristan J. Aronson18Banu K. Arun19Annelie Augustinsson20Jacopo Azzollini21Daniel Barrowdale22Caroline Baynes23Heko Becher24Marina Bermisheva25Leslie Bernstein26Katarzyna Białkowska27Carl Blomqvist28Stig E. Bojesen29Bernardo Bonanni30Ake Borg31Hiltrud Brauch32Hermann Brenner33Barbara Burwinkel34Saundra S. Buys35Trinidad Caldés36Maria A. Caligo37Daniele Campa38Brian D. Carter39Jose E. Castelao40Jenny Chang-Claude41Stephen J. Chanock42Wendy K. Chung43Kathleen B. M. Claes44Christine L. Clarke45GEMO Study CollaboratorsEMBRACE CollaboratorsJ. Margriet Collée46Don M. Conroy47Kamila Czene48Mary B. Daly49Peter Devilee50Orland Diez51Yuan Chun Ding52Susan M. Domchek53Thilo Dörk54Isabel dos-Santos-Silva55Alison M. Dunning56Miriam Dwek57Diana M. Eccles58A. Heather Eliassen59Christoph Engel60Mikael Eriksson61D. Gareth Evans62Peter A. Fasching63Henrik Flyger64Florentia Fostira65Eitan Friedman66Lin Fritschi67Debra Frost68Manuela Gago-Dominguez69Susan M. Gapstur70Judy Garber71Vanesa Garcia-Barberan72Montserrat García-Closas73José A. García-Sáenz74Mia M. Gaudet75Simon A. Gayther76Andrea Gehrig77Vassilios Georgoulias78Graham G. Giles79Andrew K. Godwin80Mark S. Goldberg81David E. Goldgar82Anna González-Neira83Mark H. Greene84Pascal Guénel85Lothar Haeberle86Eric Hahnen87Christopher A. Haiman88Niclas Håkansson89Per Hall90Ute Hamann91Patricia A. Harrington92Steven N. Hart93Wei He94Frans B. L. Hogervorst95Antoinette Hollestelle96John L. Hopper97Darling J. Horcasitas98Peter J. Hulick99David J. Hunter100Evgeny N. Imyanitov101KConFab InvestigatorsHEBON InvestigatorsABCTB InvestigatorsAgnes Jager102Anna Jakubowska103Paul A. James104Uffe Birk Jensen105Esther M. John106Michael E. Jones107Rudolf Kaaks108Pooja Middha Kapoor109Beth Y. Karlan110Renske Keeman111Elza Khusnutdinova112Johanna I. Kiiski113Yon-Dschun Ko114Veli-Matti Kosma115Peter Kraft116Allison W. Kurian117Yael Laitman118Diether Lambrechts119Loic Le Marchand120Jenny Lester121Fabienne Lesueur122Tricia Lindstrom123Adria Lopez-Fernández124Jennifer T. Loud125Craig Luccarini126Arto Mannermaa127Siranoush Manoukian128Sara Margolin129John W. M. Martens130Noura Mebirouk131Alfons Meindl132Austin Miller133Roger L. Milne134Marco Montagna135Katherine L. Nathanson136Susan L. Neuhausen137Heli Nevanlinna138Finn C. Nielsen139Katie M. O’Brien140Olufunmilayo I. Olopade141Janet E. Olson142Håkan Olsson143Ana Osorio144Laura Ottini145Tjoung-Won Park-Simon146Michael T. Parsons147Inge Sokilde Pedersen148Beth Peshkin149Paolo Peterlongo150Julian Peto151Paul D. P. Pharoah152Kelly-Anne Phillips153Eric C. Polley154Bruce Poppe155Nadege Presneau156Miquel Angel Pujana157Kevin Punie158Paolo Radice159Johanna Rantala160Muhammad U. Rashid161Gad Rennert162Hedy S. Rennert163Mark Robson164Atocha Romero165Maria Rossing166Emmanouil Saloustros167Dale P. Sandler168Regina Santella169Maren T. Scheuner170Marjanka K. Schmidt171Gunnar Schmidt172Christopher Scott173Priyanka Sharma174Penny Soucy175Melissa C. Southey176John J. Spinelli177Zoe Steinsnyder178Jennifer Stone179Dominique Stoppa-Lyonnet180Anthony Swerdlow181Rulla M. Tamimi182William J. Tapper183Jack A. Taylor184Mary Beth Terry185Alex Teulé186Darcy L. Thull187Marc Tischkowitz188Amanda E. Toland189Diana Torres190Alison H. Trainer191Thérèse Truong192Nadine Tung193Celine M. Vachon194Ana Vega195Joseph Vijai196Qin Wang197Barbara Wappenschmidt198Clarice R. Weinberg199Jeffrey N. Weitzel200Camilla Wendt201Alicja Wolk202Siddhartha Yadav203Xiaohong R. Yang204Drakoulis Yannoukakos205Wei Zheng206Argyrios Ziogas207Kristin K. Zorn208Sue K. Park209Mads Thomassen210Kenneth Offit211Rita K. Schmutzler212Fergus J. Couch213Jacques Simard214Georgia Chenevix-Trench215Douglas F. Easton216Nadine Andrieu217Antonis C. Antoniou218Genetic Epidemiology of Cancer team, Inserm, U900Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of CambridgeDepartment of Genetics and Computational Biology QIMR Berghofer Medical Research InstituteDepartment of Genetics and Computational Biology QIMR Berghofer Medical Research InstituteCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of CambridgeCentre for Cancer Genetic Epidemiology, Department of Oncology University of CambridgeCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of CambridgeCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of CambridgeCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of CambridgeCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of CambridgeFamily Cancer Clinic, The Netherlands Cancer Institute, Antoni van Leeuwenhoek hospitalImmunology and Molecular Oncology, Unit Veneto Institute of Oncology IOV – IRCCSDivision of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health, Department of Health and Human ServicesDepartment of Clinical Genetics, Helsinki University Hospital University of HelsinkiFred A. Litwin Center for Cancer Genetics Lunenfeld-Tanenbaum Research Institute of Mount Sinai HospitalDepartment of Epidemiology, Genetic Epidemiology Research Institute University of California IrvineDivision of Clinical Epidemiology and Aging Research German Cancer Research Center (DKFZ)Department of Gynaecology and Obstetrics University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University KielDepartment of Public Health Sciences, and Cancer Research Institute Queen’s UniversityDepartment of Breast Medical Oncology University of Texas MD Anderson Cancer CenterDepartment of Cancer Epidemiology, Clinical Sciences Lund UniversityUnit of Medical Genetics, Department of Medical Oncology and Hematology Fondazione IRCCS Istituto Nazionale dei Tumori di MilanoCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of CambridgeCentre for Cancer Genetic Epidemiology, Department of Oncology University of CambridgeInstitute for Medical Biometrics and Epidemiology University Medical Center Hamburg-EppendorfInstitute of Biochemistry and Genetics Ufa Federal Research Centre of the Russian Academy of SciencesDepartment of Population Sciences Beckman Research Institute of City of HopeDepartment of Genetics and Pathology Pomeranian Medical University SzczecinDepartment of Oncology, Helsinki University Hospital University of HelsinkiCopenhagen General Population Study, Herlev and Gentofte Hospital Copenhagen University HospitalDivision of Cancer Prevention and Genetics IEO, European Institute of Oncology IRCCSDepartment of Oncology Lund University and Skåne University HospitalDr. Margarete Fischer-Bosch-Institute of Clinical PharmacologyDivision of Clinical Epidemiology and Aging Research German Cancer Research Center (DKFZ)Molecular Epidemiology Group, C080 German Cancer Research Center (DKFZ)Department of Medicine Huntsman Cancer InstituteMolecular Oncology Laboratory CIBERONC, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)SOD Genetica Molecolare University HospitalDepartment of Biology University of PisaBehavioral and Epidemiology Research Group American Cancer Society AtlantaOncology and Genetics Unit Instituto de Investigacion Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGASDivision of Cancer Epidemiology German Cancer Research Center (DKFZ)Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health, Department of Health and Human ServicesDepartments of Pediatrics and Medicine, Columbia UniversityCentre for Medical Genetics Ghent UniversityWestmead Institute for Medical Research University of SydneyDepartment of Clinical Genetics Erasmus University Medical CenterCentre for Cancer Genetic Epidemiology, Department of Oncology University of CambridgeDepartment of Medical Epidemiology and Biostatistics, Karolinska InstitutetDepartment of Clinical Genetics Fox Chase Cancer Center PhiladelphiaDepartment of Pathology Leiden University Medical CenterOncogenetics Group Vall d’Hebron Institute of Oncology (VHIO)Department of Population Sciences Beckman Research Institute of City of HopeBasser Center for BRCA, Abramson Cancer Center University of PennsylvaniaGynaecology Research Unit, Hannover Medical SchoolDepartment of Non-Communicable Disease Epidemiology London School of Hygiene and Tropical MedicineCentre for Cancer Genetic Epidemiology, Department of Oncology University of CambridgeSchool of Life Sciences University of WestminsterFaculty of Medicine University of SouthamptonChanning Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolInstitute for Medical Informatics, Statistics and Epidemiology University of LeipzigDepartment of Medical Epidemiology and Biostatistics, Karolinska InstitutetGenomic Medicine, Division of Evolution and Genomic Sciences The University of Manchester, Manchester Academic Health Science Centre, Manchester Universities Foundation Trust, St Mary’s HospitalDavid Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology University of California at Los AngelesDepartment of Breast Surgery, Herlev and Gentofte Hospital Copenhagen University HospitalMolecular Diagnostics Laboratory, INRASTES National Centre for Scientific Research íDemokritosíThe Susanne Levy Gertner Oncogenetics Unit Chaim Sheba Medical CenterSchool of Public Health Curtin UniversityCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of CambridgeGenomic Medicine Group, Galician Foundation of Genomic Medicine Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGASBehavioral and Epidemiology Research Group American Cancer Society AtlantaDivision of Cancer Genetics and Prevention, Dana-Farber Cancer InstituteMedical Oncology Department, Hospital Clínico San Carlos Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC)Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health, Department of Health and Human ServicesMedical Oncology Department, Hospital Clínico San Carlos Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC)Behavioral and Epidemiology Research Group American Cancer Society AtlantaCenter for Bioinformatics and Functional Genomics and the Cedars Sinai Genomics Core Cedars-Sinai Medical CenterDepartment of Human Genetics University WürzburgDepartment of Medical Oncology University Hospital of HeraklionCancer Epidemiology Division Cancer Council VictoriaDepartment of Pathology and Laboratory Medicine, University of Kansas Medical CenterDepartment of Medicine, McGill UniversityHuntsman Cancer Institute and Department of Dermatology, University of Utah School of MedicineHuman Cancer Genetics Programme Spanish National Cancer Research Centre (CNIO)Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics National Cancer InstituteCancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP) INSERM, University Paris-Sud, University Paris-SaclayDepartment of Gynaecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMNCenter for Hereditary Breast and Ovarian Cancer Faculty of Medicine and University Hospital Cologne, University of CologneDepartment of Preventive Medicine, Keck School of Medicine University of Southern CaliforniaDepartment of Oncology, SödersjukhusetDepartment of Medical Epidemiology and Biostatistics, Karolinska InstitutetMolecular Genetics of Breast Cancer German Cancer Research Center (DKFZ)Centre for Cancer Genetic Epidemiology, Department of Oncology University of CambridgeDepartment of Health Sciences Research, Mayo ClinicDepartment of Medical Epidemiology and Biostatistics, Karolinska InstitutetFamily Cancer Clinic, The Netherlands Cancer Institute, Antoni van Leeuwenhoek hospitalDepartment of Medical Oncology, Family Cancer Clinic Erasmus MC Cancer InstituteCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of MelbourneNew Mexico Oncology Hematology Consultants, University of New MexicoCenter for Medical Genetics NorthShore University HealthSystemDepartment of Epidemiology Harvard TH Chan School of Public HealthNN Petrov Institute of OncologyDepartment of Medical Oncology, Family Cancer Clinic Erasmus MC Cancer InstituteDepartment of Genetics and Pathology Pomeranian Medical University SzczecinSir Peter MacCallum Department of Oncology The University of MelbourneDepartment of Clinical Genetics Aarhus, University HospitalDepartment of Medicine, Division of Oncology, Stanford University School of MedicineDepartment of Epidemiology and Population Health, Stanford University School of MedicineDivision of Cancer Epidemiology German Cancer Research Center (DKFZ)Division of Cancer Epidemiology German Cancer Research Center (DKFZ)Faculty of Medicine University of HeidelbergWomenís Cancer Program at the Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical CenterInstitute of Biochemistry and Genetics Ufa Federal Research Centre of the Russian Academy of SciencesDepartment of Genetics and Fundamental Medicine Bashkir State Medical UniversityDepartment of Obstetrics and Gynecology, Helsinki University Hospital University of HelsinkiDepartment of Internal Medicine, Evangelische Kliniken Bonn gGmbH Johanniter KrankenhausDepartment of Epidemiology Harvard TH Chan School of Public HealthDepartment of Medicine, Division of Oncology, Stanford University School of MedicineThe Susanne Levy Gertner Oncogenetics Unit Chaim Sheba Medical CenterVIB Center for Cancer BiologyEpidemiology Program University of Hawaii Cancer CenterFaculty of Medicine University of HeidelbergGenetic Epidemiology of Cancer team, Inserm, U900Department of Health Sciences Research, Mayo ClinicHigh Risk and Cancer Prevention Group Vall d’Hebron Institute of OncologyClinical Genetics Branch, Division of Cancer Epidemiology and Genetics National Cancer InstituteCentre for Cancer Genetic Epidemiology, Department of Oncology University of CambridgeDepartment of Internal Medicine, Evangelische Kliniken Bonn gGmbH Johanniter KrankenhausUnit of Medical Genetics, Department of Medical Oncology and Hematology Fondazione IRCCS Istituto Nazionale dei Tumori di MilanoDepartment of Oncology, SödersjukhusetDepartment of Medical Oncology, Family Cancer Clinic Erasmus MC Cancer InstituteGenetic Epidemiology of Cancer team, Inserm, U900Department of Gynecology and Obstetrics University of Munich, Campus GrosshadernNRG Oncology, Statistics and Data Management Center Roswell Park Cancer InstituteCancer Epidemiology Division Cancer Council VictoriaImmunology and Molecular Oncology, Unit Veneto Institute of Oncology IOV – IRCCSBasser Center for BRCA, Abramson Cancer Center University of PennsylvaniaDepartment of Population Sciences Beckman Research Institute of City of HopeDepartment of Genetics and Fundamental Medicine Bashkir State Medical UniversityCenter for Genomic Medicine Rigshospitalet, Copenhagen University HospitalEpidemiology Branch National Institute of Environmental Health Sciences, NIH Research Triangle ParkCenter for Clinical Cancer Genetics The University of ChicagoDepartment of Health Sciences Research, Mayo ClinicDepartment of Cancer Epidemiology, Clinical Sciences Lund UniversityHuman Cancer Genetics Programme Spanish National Cancer Research Centre (CNIO)Department of Molecular Medicine University La SapienzaGynaecology Research Unit, Hannover Medical SchoolDepartment of Genetics and Computational Biology QIMR Berghofer Medical Research InstituteMolecular Diagnostics Aalborg University HospitalLombardi Comprehensive Cancer Center, Georgetown UniversityGenome Diagnostics Program IFOM - the FIRC (Italian Foundation for Cancer Research) Institute of Molecular OncologyDepartment of Non-Communicable Disease Epidemiology London School of Hygiene and Tropical MedicineCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of CambridgeDepartment of Genetics and Computational Biology QIMR Berghofer Medical Research InstituteDepartment of Health Sciences Research, Mayo ClinicCentre for Medical Genetics Ghent UniversitySchool of Life Sciences University of WestminsterTranslational Research Laboratory IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONCLeuven Multidisciplinary Breast Center, Department of Oncology Leuven Cancer Institute, University Hospitals LeuvenUnit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research Fondazione IRCCS Istituto Nazionale dei Tumori (INT)Clinical Genetics Karolinska InstitutetMolecular Genetics of Breast Cancer German Cancer Research Center (DKFZ)Clalit National Cancer Control Center Carmel Medical Center and Technion Faculty of MedicineClalit National Cancer Control Center Carmel Medical Center and Technion Faculty of MedicineClinical Genetics Service, Department of Medicine Memorial Sloan-Kettering Cancer CenterMedical Oncology Department Hospital Universitario Puerta de HierroCenter for Genomic Medicine Rigshospitalet, Copenhagen University HospitalDepartment of Oncology University Hospital of LarissaEpidemiology Branch National Institute of Environmental Health Sciences, NIH Research Triangle ParkDepartment of Epidemiology, Mailman School of Public Health Columbia UniversityCancer Genetics and Prevention Program University of California San FranciscoWomenís Cancer Program at the Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical CenterInstitute of Human Genetics Hannover Medical SchoolDepartment of Health Sciences Research, Mayo ClinicDepartment of Internal Medicine, Division of Medical Oncology University of Kansas Medical CenterGenomics Center, Centre Hospitalier Universitaire de Québec - Université Laval Research CenterPrecision Medicine, School of Clinical Sciences at Monash Health Monash UniversityPopulation Oncology BC CancerClinical Genetics Research Lab, Department of Cancer Biology and Genetics Memorial Sloan-Kettering Cancer CenterCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of MelbourneService de Génétique Institut CurieDepartment of Epidemiology and Population Health, Stanford University School of MedicineChanning Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolFaculty of Medicine University of SouthamptonEpidemiology Branch National Institute of Environmental Health Sciences, NIH Research Triangle ParkDepartment of Epidemiology, Mailman School of Public Health Columbia UniversityHereditary Cancer Program ONCOBELL-IDIBELL-IDIBGI-IGTP, Catalan Institute of Oncology, CIBERONCDepartment of Medicine Magee-Womens Hospital, University of Pittsburgh School of MedicineProgram in Cancer Genetics, Departments of Human Genetics and Oncology McGill UniversityDepartment of Cancer Biology and Genetics The Ohio State UniversityMolecular Genetics of Breast Cancer German Cancer Research Center (DKFZ)Parkville Familial Cancer Centre Peter MacCallum Cancer CenterCancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP) INSERM, University Paris-Sud, University Paris-SaclayDepartment of Medical Oncology Beth Israel Deaconess Medical CenterDepartment of Health Science Research, Division of Epidemiology Mayo ClinicFundación Pública Galega Medicina Xenómica-SERGAS, Instituto de Investigación Sanitaria Santiago de Compostela (IDIS); CIBERERClinical Genetics Service, Department of Medicine Memorial Sloan-Kettering Cancer CenterCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of CambridgeCenter for Hereditary Breast and Ovarian Cancer Faculty of Medicine and University Hospital Cologne, University of CologneBiostatistics and Computational Biology Branch National Institute of Environmental Health Sciences, NIH Research Triangle ParkClinical Cancer Genomics City of HopeDepartment of Clinical Science and Education, Södersjukhuset Karolinska InstitutetInstitute of Environmental Medicine Karolinska InstitutetDepartment of Oncology Mayo ClinicDivision of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health, Department of Health and Human ServicesMolecular Diagnostics Laboratory, INRASTES National Centre for Scientific Research íDemokritosíDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center Vanderbilt University School of MedicineDepartment of Epidemiology, Genetic Epidemiology Research Institute University of California IrvineMagee-Womens Hospital, University of Pittsburgh School of MedicineDepartment of Preventive Medicine Seoul National University College of MedicineDepartment of Clinical Genetics Odense University HospitalClinical Genetics Service, Department of Medicine Memorial Sloan-Kettering Cancer CenterCenter for Hereditary Breast and Ovarian Cancer Faculty of Medicine and University Hospital Cologne, University of CologneDepartment of Laboratory Medicine and Pathology Mayo ClinicDepartment of Epidemiology, Genetic Epidemiology Research Institute University of California IrvineDepartment of Genetics and Computational Biology QIMR Berghofer Medical Research InstituteCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of CambridgeGenetic Epidemiology of Cancer team, Inserm, U900Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of CambridgeBreast cancer risk for BRCA1/BRCA2 mutation carriers varies depending on other genetic factors. Here, the authors perform a case-only genome-wide association study and highlight novel loci associated with breast cancer risk for BRCA1/BRCA2 mutation carriers.https://doi.org/10.1038/s41467-020-20496-3

A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Similar Items