Chromosome contacts in activated T cells identify autoimmune disease candidate genes

Chromosome contacts in activated T cells identify autoimmune disease candidate genes

Abstract Background Autoimmune disease-associated variants are preferentially found in regulatory regions in immune cells, particularly CD4+ T cells. Linking such regulatory regions to gene promoters in disease-relevant cell contexts facilitates identification of candidate disease genes. Results Wit...

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Bibliographic Details
Main Authors: Oliver S. Burren, Arcadio Rubio García, Biola-Maria Javierre, Daniel B. Rainbow, Jonathan Cairns, Nicholas J. Cooper, John J. Lambourne, Ellen Schofield, Xaquin Castro Dopico, Ricardo C. Ferreira, Richard Coulson, Frances Burden, Sophia P. Rowlston, Kate Downes, Steven W. Wingett, Mattia Frontini, Willem H. Ouwehand, Peter Fraser, Mikhail Spivakov, John A. Todd, Linda S. Wicker, Antony J. Cutler, Chris Wallace
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Genome Biology
Subjects:
Genetics
Genomics
Chromatin conformation
CD4+ T cells
CD4+ T cell activation
Autoimmune disease
Online Access:http://link.springer.com/article/10.1186/s13059-017-1285-0

Internet

http://link.springer.com/article/10.1186/s13059-017-1285-0

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