Aurantio-obtusin relaxes systemic arteries through endothelial PI3K/AKT/eNOS-dependent signaling pathway in rats

Aurantio-obtusin relaxes systemic arteries through endothelial PI3K/AKT/eNOS-dependent signaling pathway in rats

Aurantio-obtusin is a natural effective compound isolated from Semen Cassiae, which possesses hypotensive and hypolipidemic effects. Although its hypotensive effect have been clarified, mechanisms Aurantio-obtusin relaxes systemic arteries remain unclear. This study was to investigate effects and me...

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Bibliographic Details
Main Authors: Shuzhen Li, Qian Li, Xinyu Lv, Lin Liao, Weiwei Yang, Shanshan Li, Ping Lu, Daling Zhu
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:Journal of Pharmacological Sciences
Subjects:
Aurantio-obtusin
Mesenteric artery
Vasorelaxation
Nitric oxide synthase
PI3K/Akt pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861315001048

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http://www.sciencedirect.com/science/article/pii/S1347861315001048

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