KRAS/NRAS/BRAF Mutations as Potential Targets in Multiple Myeloma

KRAS/NRAS/BRAF Mutations as Potential Targets in Multiple Myeloma

In multiple myeloma the mutational profile is mainly represented by translocations involving chromosome 14 and by single nucleotide mutations, frequently involving genes implicated in the mitogen activated protein kinase (MAPK) pathway, as KRAS, NRAS, and, less frequently, BRAF. Because KRAS/NRAS/BR...

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Bibliographic Details
Main Authors: Sergiu Pasca, Ciprian Tomuleasa, Patric Teodorescu, Gabriel Ghiaur, Delia Dima, Vlad Moisoiu, Cristian Berce, Cristina Stefan, Aaron Ciechanover, Herman Einsele
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Oncology
Subjects:
multiple myeloma
KRAS
BRAF
NRAS
therapeutics
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01137/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.01137/full

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