Indoleamine 2,3-dioxygenase controls fungal loads and immunity in Paracoccidioidomicosis but is more important to susceptible than resistant hosts.

Indoleamine 2,3-dioxygenase controls fungal loads and immunity in Paracoccidioidomicosis but is more important to susceptible than resistant hosts.

Paracoccidioidomycosis, a primary fungal infection restricted to Latin America, is acquired by inhalation of fungal particles. The immunoregulatory mechanisms that control the severe and mild forms of paracoccidioidomycosis are still unclear. Indoleamine 2,3-dioxygenase (IDO), an IFN-γ induced enzym...

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Bibliographic Details
Main Authors: Eliseu F Araújo, Flávio V Loures, Silvia B Bazan, Claudia Feriotti, Adriana Pina, Alessandra S Schanoski, Tânia A Costa, Vera L G Calich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-11-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4238999?pdf=render

Internet

http://europepmc.org/articles/PMC4238999?pdf=render

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