DNA‐Grafted Hyaluronic Acid System with Enhanced Injectability and Biostability for Photo‐Controlled Osteoarthritis Gene Therapy

DNA‐Grafted Hyaluronic Acid System with Enhanced Injectability and Biostability for Photo‐Controlled Osteoarthritis Gene Therapy

Abstract Gene therapy is identified as a powerful strategy to overcome the limitations of traditional therapeutics to achieve satisfactory effects. However, various challenges related to the dosage form, delivery method, and, especially, application value, hampered the clinical transition of gene th...

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Bibliographic Details
Main Authors: Zhijie Chen, Feng Zhang, Hongbo Zhang, Liang Cheng, Kaizhe Chen, Jieliang Shen, Jin Qi, Lianfu Deng, Chuan He, Hélder A. Santos, Wenguo Cui
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Advanced Science
Subjects:
anti‐inflammation
DNA grafted hyaluronic acid
enhanced injectability
long‐term bio‐stability
osteoarthritis gene therapy
spherical nucleic acids
Online Access:https://doi.org/10.1002/advs.202004793

Internet

https://doi.org/10.1002/advs.202004793

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