Activation of pro-survival metabolic networks by 1,25(OH)2D3 does not hamper the sensitivity of breast cancer cells to chemotherapeutics

Activation of pro-survival metabolic networks by 1,25(OH)2D3 does not hamper the sensitivity of breast cancer cells to chemotherapeutics

Abstract Background We have previously identified 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the bioactive form of vitamin D3, as a potent regulator of energy-utilization and nutrient-sensing pathways in prostate cancer cells. In the current study, we investigated the effects of 1,25(OH)2D3 on breast c...

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Bibliographic Details
Main Authors: Mohamed A. Abu el Maaty, Yasamin Dabiri, Fadi Almouhanna, Biljana Blagojevic, Jannick Theobald, Michael Büttner, Stefan Wölfl
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Cancer & Metabolism
Subjects:
Vitamin D
Breast cancer
Metabolism
G6PD
TXNIP
AMPK
Online Access:http://link.springer.com/article/10.1186/s40170-018-0183-6

Internet

http://link.springer.com/article/10.1186/s40170-018-0183-6

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