Preclinical Evaluation of the Acute Radiotoxicity of the α-Emitting Molecular-Targeted Therapeutic Agent 211At-MABG for the Treatment of Malignant Pheochromocytoma in Normal Mice

Preclinical Evaluation of the Acute Radiotoxicity of the α-Emitting Molecular-Targeted Therapeutic Agent 211At-MABG for the Treatment of Malignant Pheochromocytoma in Normal Mice

The α-emitter 211At-labeled meta-astatobenzylguanidine (211At-MABG) has a strong antitumor effect on pheochromocytoma xenograft tumors and holds great promise as a new therapeutic option for malignant pheochromocytoma. To evaluate the acute radiation-related toxicity of 211At-MABG, we conducted biod...

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Bibliographic Details
Main Authors: Hitomi Sudo, Atsushi B. Tsuji, Aya Sugyo, Kotaro Nagatsu, Katsuyuki Minegishi, Noriko S. Ishioka, Hiroshi Ito, Keiichiro Yoshinaga, Tatsuya Higashi
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523319301147

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http://www.sciencedirect.com/science/article/pii/S1936523319301147

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