Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5+ Intestinal Stem Cells

Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5+ Intestinal Stem Cells

Lgr5+ intestinal stem cells (ISCs) drive epithelial self-renewal, and their immediate progeny—intestinal bipotential progenitors—produce absorptive and secretory lineages via lateral inhibition. To define features of early transit from the ISC compartment, we used a microfluidics approach to measure...

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Bibliographic Details
Main Authors: Tae-Hee Kim, Assieh Saadatpour, Guoji Guo, Madhurima Saxena, Alessia Cavazza, Niyati Desai, Unmesh Jadhav, Lan Jiang, Miguel N. Rivera, Stuart H. Orkin, Guo-Cheng Yuan, Ramesh A. Shivdasani
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716309871

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http://www.sciencedirect.com/science/article/pii/S2211124716309871

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