PTPσ inhibitors promote hematopoietic stem cell regeneration

PTPσ inhibitors promote hematopoietic stem cell regeneration

Protein tyrosine phosphatase sigma (PTPσ) deficient haematopoietic stem cells (HSCs) demonstrate increased engraftment following transplantation. Here the authors identify a small molecule inhibitor of PTPσ that promotes murine and human haematopoietic stem cell regeneration via induction of the RAC...

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Bibliographic Details
Main Authors: Yurun Zhang, Martina Roos, Heather Himburg, Christina M. Termini, Mamle Quarmyne, Michelle Li, Liman Zhao, Jenny Kan, Tiancheng Fang, Xiao Yan, Katherine Pohl, Emelyne Diers, Hyo Jin Gim, Robert Damoiseaux, Julian Whitelegge, William McBride, Michael E. Jung, John P. Chute
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11490-5

Internet

https://doi.org/10.1038/s41467-019-11490-5

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