Cartilage endoplasmic reticulum stress may influence the onset but not the progression of experimental osteoarthritis

Cartilage endoplasmic reticulum stress may influence the onset but not the progression of experimental osteoarthritis

Abstract Background Osteoarthritis has been associated with a plethora of pathological factors and one which has recently emerged is chondrocyte endoplasmic reticulum (ER) stress. ER stress is sensed by key ER-resident stress sensors, one of which is activating transcription factor 6 (ATF6). The pur...

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Bibliographic Details
Main Authors: Louise H. W. Kung, Lorna Mullan, Jamie Soul, Ping Wang, Kazutoshi Mori, John F. Bateman, Michael D. Briggs, Raymond P. Boot-Handford
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Arthritis Research & Therapy
Subjects:
Endoplasmic reticulum (ER) stress
Osteoarthritis
Mouse
Medial meniscus destabilisation (DMM)
ATF6α
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s13075-019-1988-6

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http://link.springer.com/article/10.1186/s13075-019-1988-6

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