Synthesis of Indofulvin Pseudo‐Natural Products Yields a New Autophagy Inhibitor Chemotype

Synthesis of Indofulvin Pseudo‐Natural Products Yields a New Autophagy Inhibitor Chemotype

Abstract Chemical and biological limitations in bioactive compound design based on natural product (NP) structure can be overcome by the combination of NP‐derived fragments in unprecedented arrangements to afford “pseudo‐natural products” (pseudo‐NPs). A new pseudo‐NP design principle is described,...

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Bibliographic Details
Main Authors: Annina Burhop, Sukdev Bag, Michael Grigalunas, Sophie Woitalla, Pia Bodenbinder, Lukas Brieger, Carsten Strohmann, Axel Pahl, Sonja Sievers, Herbert Waldmann
Format: Article
Language:English
Published: Wiley 2021-10-01
Series:Advanced Science
Subjects:
autophagy
cell painting
oxa‐Pictet‐Spengler reaction
pseudo‐natural products
Online Access:https://doi.org/10.1002/advs.202102042

Internet

https://doi.org/10.1002/advs.202102042

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