Inflammation kinase PKR phosphorylates α-synuclein and causes α-synuclein-dependent cell death

Inflammation kinase PKR phosphorylates α-synuclein and causes α-synuclein-dependent cell death

Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy comprise a group of neurodegenerative diseases termed synucleinopathies. Synucleinopathie are, characterized by presence of inclusion bodies in degenerating brain cells which contain aggregated α-synuclein phosphorylate...

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Bibliographic Details
Main Authors: Lasse Reimer, Louise Buur Vesterager, Cristine Betzer, Jin Zheng, Lærke Dalsgaard Nielsen, Rikke Hahn Kofoed, Louise Berkhoudt Lassen, Ulrik Bølcho, Søren Riis Paludan, Karina Fog, Poul Henning Jensen
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:Neurobiology of Disease
Subjects:
Neurodegeneration
Synucleinopathies
Alpha-Synuclein
PKR
EIF2AK2
Phosphorylation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118300627

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http://www.sciencedirect.com/science/article/pii/S0969996118300627

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