Bacteroides thetaiotaomicron-derived outer membrane vesicles promote regulatory dendritic cell responses in health but not in inflammatory bowel disease

Bacteroides thetaiotaomicron-derived outer membrane vesicles promote regulatory dendritic cell responses in health but not in inflammatory bowel disease

Abstract Background Bacteroides thetaiotaomicron (Bt) is a prominent member of the human intestinal microbiota that, like all gram-negative bacteria, naturally generates nanosized outer membrane vesicles (OMVs) which bud off from the cell surface. Importantly, OMVs can cross the intestinal epithelia...

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Bibliographic Details
Main Authors: Lydia Durant, Régis Stentz, Alistair Noble, Johanne Brooks, Nadezhda Gicheva, Durga Reddi, Matthew J. O’Connor, Lesley Hoyles, Anne L. McCartney, Ripple Man, E. Tobias Pring, Stella Dilke, Philip Hendy, Jonathan P. Segal, Dennis N. F. Lim, Ravi Misra, Ailsa L. Hart, Naila Arebi, Simon R. Carding, Stella C. Knight
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Microbiome
Subjects:
Dendritic cells
Outer membrane vesicles
Bacteroides thetaiotaomicron
Interleukin-10
Inflammatory bowel disease
Online Access:http://link.springer.com/article/10.1186/s40168-020-00868-z

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http://link.springer.com/article/10.1186/s40168-020-00868-z

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