Pharmacokinetics and pharmacodynamics of sildenafil in fetal lambs on extracorporeal support

Pharmacokinetics and pharmacodynamics of sildenafil in fetal lambs on extracorporeal support

Background: Maternal transplacental administration of sildenafil is being considered for a variety of fetal conditions. Clinical translation also requires evaluation of fetal safety in a higher species, such as the fetal lamb. Experiments with the pregnant ewe are curtailed by minimal transplacental...

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Bibliographic Details
Main Authors: Felix R. De Bie, Francesca M. Russo, Pieter Van Brantegem, Barbara E. Coons, James K. Moon, Zexuan Yang, Chengcheng Pang, Janaina C. Senra, Camilla Omann, Pieter Annaert, Karel Allegaert, Marcus G. Davey, Alan W. Flake, Jan Deprest
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Sildenafil citrate
Fetal therapies
Fetal lamb
Extracorporeal circulation
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221009458

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http://www.sciencedirect.com/science/article/pii/S0753332221009458

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