Anatomic Origin of Osteochondrogenic Progenitors Impacts Sensitivity to EWS-FLI1-Induced Transformation

Anatomic Origin of Osteochondrogenic Progenitors Impacts Sensitivity to EWS-FLI1-Induced Transformation

Ewing sarcomas predominantly arise in pelvic and stylopod bones (i.e., femur and humerus), likely as a consequence of EWS-FLI1 oncogene-induced transformation of mesenchymal stem/progenitor cells (MSCs). MSCs located in the embryonic superficial zone cells (eSZ) of limbs express anatomically distinc...

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Bibliographic Details
Main Authors: Elise R. Pfaltzgraff, April Apfelbaum, Andrew P. Kassa, Jane Y. Song, Wei Jiang, Tahra K. Suhan, Deneen M. Wellik, Elizabeth R. Lawlor
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cancers
Subjects:
Ewing sarcoma
Hox
cell of origin
mesenchymal progenitor cells
MSCs
Online Access:http://www.mdpi.com/2072-6694/11/3/313

Internet

http://www.mdpi.com/2072-6694/11/3/313

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