Anatomic Origin of Osteochondrogenic Progenitors Impacts Sensitivity to EWS-FLI1-Induced Transformation
Ewing sarcomas predominantly arise in pelvic and stylopod bones (i.e., femur and humerus), likely as a consequence of EWS-FLI1 oncogene-induced transformation of mesenchymal stem/progenitor cells (MSCs). MSCs located in the embryonic superficial zone cells (eSZ) of limbs express anatomically distinc...
Main Authors: | Elise R. Pfaltzgraff, April Apfelbaum, Andrew P. Kassa, Jane Y. Song, Wei Jiang, Tahra K. Suhan, Deneen M. Wellik, Elizabeth R. Lawlor |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-03-01
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Series: | Cancers |
Subjects: | |
Online Access: | http://www.mdpi.com/2072-6694/11/3/313 |
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