Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis

Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis

Abstract Background High throughput single-cell RNA sequencing (scRNA-Seq) has emerged as a powerful tool for exploring cellular heterogeneity among complex human cancers. scRNA-Seq studies using fresh human surgical tissue are logistically difficult, preclude histopathological triage of samples, an...

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Main Authors: Sunny Z. Wu, Daniel L. Roden, Ghamdan Al-Eryani, Nenad Bartonicek, Kate Harvey, Aurélie S. Cazet, Chia-Ling Chan, Simon Junankar, Mun N. Hui, Ewan A. Millar, Julia Beretov, Lisa Horvath, Anthony M. Joshua, Phillip Stricker, James S. Wilmott, Camelia Quek, Georgina V. Long, Richard A. Scolyer, Bertrand Z. Yeung, Davendra Segara, Cindy Mak, Sanjay Warrier, Joseph E. Powell, Sandra O’Toole, Elgene Lim, Alexander Swarbrick
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Genome Medicine
Subjects:
Single-cell RNA sequencing
Cryopreservation
Tumour heterogeneity
CITE-Seq
Breast cancer
Prostate cancer
Online Access:https://doi.org/10.1186/s13073-021-00885-z

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