Independence of HIF1a and androgen signaling pathways in prostate cancer

Independence of HIF1a and androgen signaling pathways in prostate cancer

Abstract Background Therapeutic targeting of the androgen signaling pathway is a mainstay treatment for prostate cancer. Although initially effective, resistance to androgen targeted therapies develops followed by disease progression to castrate-resistant prostate cancer (CRPC). Hypoxia and HIF1a ha...

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Bibliographic Details
Main Authors: Maxine G. B. Tran, Becky A. S. Bibby, Lingjian Yang, Franklin Lo, Anne Y. Warren, Deepa Shukla, Michelle Osborne, James Hadfield, Thomas Carroll, Rory Stark, Helen Scott, Antonio Ramos-Montoya, Charlie Massie, Patrick Maxwell, Catharine M. L. West, Ian G. Mills, David E. Neal
Format: Article
Language:English
Published: BMC 2020-05-01
Series:BMC Cancer
Subjects:
Prostate cancer
Androgen signaling
HIF1a signaling
Hypoxia
Online Access:http://link.springer.com/article/10.1186/s12885-020-06890-6

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http://link.springer.com/article/10.1186/s12885-020-06890-6

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