Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia

Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia

Ten-eleven translocation 1 (TET1) is a critical oncoprotein in AML. Here, the authors identify 2 compounds that target the binding of STAT3/5 specifically to the TET1 promoter, inhibiting its expression and AML cell viability.

Bibliographic Details
Main Authors: Xi Jiang, Chao Hu, Kyle Ferchen, Ji Nie, Xiaolong Cui, Chih-Hong Chen, Liting Cheng, Zhixiang Zuo, William Seibel, Chunjiang He, Yixuan Tang, Jennifer R. Skibbe, Mark Wunderlich, William C. Reinhold, Lei Dong, Chao Shen, Stephen Arnovitz, Bryan Ulrich, Jiuwei Lu, Hengyou Weng, Rui Su, Huilin Huang, Yungui Wang, Chenying Li, Xi Qin, James C. Mulloy, Yi Zheng, Jiajie Diao, Jie Jin, Chong Li, Paul P. Liu, Chuan He, Yuan Chen, Jianjun Chen
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02290-w

Internet

https://doi.org/10.1038/s41467-017-02290-w

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