Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming.

Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming.

Immature dendritic cells (DCs) maintain a highly dynamic pool of recycling MHCII that promotes sampling of environmental antigens for presentation to T helper cells. However, the molecular basis of MHCII recycling and the cellular machinery that orchestrates MHCII trafficking are incompletely unders...

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Bibliographic Details
Main Authors: Daniel B Graham, Douglas G Osborne, Joshua T Piotrowski, Timothy S Gomez, Grzegorz B Gmyrek, Holly M Akilesh, Adish Dani, Daniel D Billadeau, Wojciech Swat
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4041763?pdf=render

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http://europepmc.org/articles/PMC4041763?pdf=render

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