Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal.

Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal.

<h4>Background</h4>The continued advance of antibiotic resistance threatens the treatment and control of many infectious diseases. This is exemplified by the largest global outbreak of extensively drug-resistant (XDR) tuberculosis (TB) identified in Tugela Ferry, KwaZulu-Natal, South Afr...

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Main Authors: Keira A Cohen, Thomas Abeel, Abigail Manson McGuire, Christopher A Desjardins, Vanisha Munsamy, Terrance P Shea, Bruce J Walker, Nonkqubela Bantubani, Deepak V Almeida, Lucia Alvarado, Sinéad B Chapman, Nomonde R Mvelase, Eamon Y Duffy, Michael G Fitzgerald, Pamla Govender, Sharvari Gujja, Susanna Hamilton, Clinton Howarth, Jeffrey D Larimer, Kashmeel Maharaj, Matthew D Pearson, Margaret E Priest, Qiandong Zeng, Nesri Padayatchi, Jacques Grosset, Sarah K Young, Jennifer Wortman, Koleka P Mlisana, Max R O'Donnell, Bruce W Birren, William R Bishai, Alexander S Pym, Ashlee M Earl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-09-01
Series:PLoS Medicine
Online Access:https://doi.org/10.1371/journal.pmed.1001880

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