The Cyclooctadepsipeptide Anthelmintic Emodepside Differentially Modulates Nematode, Insect and Human Calcium-Activated Potassium (SLO) Channel Alpha Subunits.

The Cyclooctadepsipeptide Anthelmintic Emodepside Differentially Modulates Nematode, Insect and Human Calcium-Activated Potassium (SLO) Channel Alpha Subunits.

The anthelmintic emodepside paralyses adult filarial worms, via a mode of action distinct from previous anthelmintics and has recently garnered interest as a new treatment for onchocerciasis. Whole organism data suggest its anthelmintic action is underpinned by a selective activation of the nematode...

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Main Authors: Anna Crisford, Ulrich Ebbinghaus-Kintscher, Eva Schoenhense, Achim Harder, Klaus Raming, Ita O'Kelly, Kelechi Ndukwe, Vincent O'Connor, Robert J Walker, Lindy Holden-Dye
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4593646?pdf=render

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http://europepmc.org/articles/PMC4593646?pdf=render

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