Yeast as a Model System to Study Tau Biology

Yeast as a Model System to Study Tau Biology

Hyperphosphorylated and aggregated human protein tau constitutes a hallmark of a multitude of neurodegenerative diseases called tauopathies, exemplified by Alzheimer's disease. In spite of an enormous amount of research performed on tau biology, several crucial questions concerning the mechanis...

Full description

Bibliographic Details
Main Authors: Ann De Vos, Jayamani Anandhakumar, Jeff Van den Brande, Mathias Verduyckt, Vanessa Franssens, Joris Winderickx, Erwin Swinnen
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:International Journal of Alzheimer's Disease
Online Access:http://dx.doi.org/10.4061/2011/428970
id doaj-a74afcec3dfd438fb554d2f660cbcda4
record_format Article
spelling doaj-a74afcec3dfd438fb554d2f660cbcda42020-11-24T22:10:11ZengHindawi LimitedInternational Journal of Alzheimer's Disease2090-02522011-01-01201110.4061/2011/428970428970Yeast as a Model System to Study Tau BiologyAnn De Vos0Jayamani Anandhakumar1Jeff Van den Brande2Mathias Verduyckt3Vanessa Franssens4Joris Winderickx5Erwin Swinnen6Laboratory of Functional Biology, Catholic University of Leuven, Kasteelpark Arenberg 31, 3001 Heverlee, BelgiumLaboratory of Functional Biology, Catholic University of Leuven, Kasteelpark Arenberg 31, 3001 Heverlee, BelgiumLaboratory of Functional Biology, Catholic University of Leuven, Kasteelpark Arenberg 31, 3001 Heverlee, BelgiumLaboratory of Functional Biology, Catholic University of Leuven, Kasteelpark Arenberg 31, 3001 Heverlee, BelgiumLaboratory of Functional Biology, Catholic University of Leuven, Kasteelpark Arenberg 31, 3001 Heverlee, BelgiumLaboratory of Functional Biology, Catholic University of Leuven, Kasteelpark Arenberg 31, 3001 Heverlee, BelgiumLaboratory of Functional Biology, Catholic University of Leuven, Kasteelpark Arenberg 31, 3001 Heverlee, BelgiumHyperphosphorylated and aggregated human protein tau constitutes a hallmark of a multitude of neurodegenerative diseases called tauopathies, exemplified by Alzheimer's disease. In spite of an enormous amount of research performed on tau biology, several crucial questions concerning the mechanisms of tau toxicity remain unanswered. In this paper we will highlight some of the processes involved in tau biology and pathology, focusing on tau phosphorylation and the interplay with oxidative stress. In addition, we will introduce the development of a human tau-expressing yeast model, and discuss some crucial results obtained in this model, highlighting its potential in the elucidation of cellular processes leading to tau toxicity.http://dx.doi.org/10.4061/2011/428970
collection DOAJ
language English
format Article
sources DOAJ
author Ann De Vos
Jayamani Anandhakumar
Jeff Van den Brande
Mathias Verduyckt
Vanessa Franssens
Joris Winderickx
Erwin Swinnen
spellingShingle Ann De Vos
Jayamani Anandhakumar
Jeff Van den Brande
Mathias Verduyckt
Vanessa Franssens
Joris Winderickx
Erwin Swinnen
Yeast as a Model System to Study Tau Biology
International Journal of Alzheimer's Disease
author_facet Ann De Vos
Jayamani Anandhakumar
Jeff Van den Brande
Mathias Verduyckt
Vanessa Franssens
Joris Winderickx
Erwin Swinnen
author_sort Ann De Vos
title Yeast as a Model System to Study Tau Biology
title_short Yeast as a Model System to Study Tau Biology
title_full Yeast as a Model System to Study Tau Biology
title_fullStr Yeast as a Model System to Study Tau Biology
title_full_unstemmed Yeast as a Model System to Study Tau Biology
title_sort yeast as a model system to study tau biology
publisher Hindawi Limited
series International Journal of Alzheimer's Disease
issn 2090-0252
publishDate 2011-01-01
description Hyperphosphorylated and aggregated human protein tau constitutes a hallmark of a multitude of neurodegenerative diseases called tauopathies, exemplified by Alzheimer's disease. In spite of an enormous amount of research performed on tau biology, several crucial questions concerning the mechanisms of tau toxicity remain unanswered. In this paper we will highlight some of the processes involved in tau biology and pathology, focusing on tau phosphorylation and the interplay with oxidative stress. In addition, we will introduce the development of a human tau-expressing yeast model, and discuss some crucial results obtained in this model, highlighting its potential in the elucidation of cellular processes leading to tau toxicity.
url http://dx.doi.org/10.4061/2011/428970
work_keys_str_mv AT anndevos yeastasamodelsystemtostudytaubiology
AT jayamanianandhakumar yeastasamodelsystemtostudytaubiology
AT jeffvandenbrande yeastasamodelsystemtostudytaubiology
AT mathiasverduyckt yeastasamodelsystemtostudytaubiology
AT vanessafranssens yeastasamodelsystemtostudytaubiology
AT joriswinderickx yeastasamodelsystemtostudytaubiology
AT erwinswinnen yeastasamodelsystemtostudytaubiology
_version_ 1725808816952442880

Similar Items