Yeasts as Complementary Model Systems for the Study of the Pathological Repercussions of Enhanced Synphilin-1 Glycation and Oxidation

by David Seynnaeve, Daniel P. Mulvihill, Joris Winderickx, Vanessa Franssens
Published 2021-02-01

A Mitochondria-Associated Oxidative Stress Perspective on Huntington’s Disease

by Ju Zheng, Ju Zheng, Ju Zheng, Joris Winderickx, Vanessa Franssens, Beidong Liu, Beidong Liu, Beidong Liu
Published 2018-09-01

Yeast as a Model System to Study Tau Biology

by Ann De Vos, Jayamani Anandhakumar, Jeff Van den Brande, Mathias Verduyckt, Vanessa Franssens, Joris Winderickx, Erwin Swinnen
Published 2011-01-01

The peptidyl prolyl cis/trans isomerase Pin1/Ess1 inhibits phosphorylation and toxicity of tau in a yeast model for Alzheimer’s disease

by Ann De Vos, Tine Bynens, Joëlle Rosseels, Catherina Coun, Julia Ring, Frank Madeo, Marie-Christine Galas, Joris Winderickx, Vanessa Franssens
Published 2015-04-01

Recent Insights on Alzheimer’s Disease Originating from Yeast Models

by David Seynnaeve, Mara Del Vecchio, Gernot Fruhmann, Joke Verelst, Melody Cools, Jimmy Beckers, Daniel P. Mulvihill, Joris Winderickx, Vanessa Franssens
Published 2018-07-01

Decreased Vacuolar Ca2+ Storage and Disrupted Vesicle Trafficking Underlie Alpha-Synuclein-Induced Ca2+ Dysregulation in S. cerevisiae

by Geert Callewaert, Petra D’hooge, Tien-Yang Ma, Tien-Yang Ma, Mara Del Vecchio, Vincent Van Eyck, Vanessa Franssens, Joris Winderickx
Published 2020-05-01

Synphilin-1 enhances α-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner.

by Sabrina Büttner, Charlotte Delay, Vanessa Franssens, Tine Bammens, Doris Ruli, Sandra Zaunschirm, Rita Machado de Oliveira, Tiago Fleming Outeiro, Frank Madeo, Luc Buée, Marie-Christine Galas, Joris Winderickx
Published 2010-10-01

The yeast protein kinase Sch9 adjusts V-ATPase assembly/disassembly to control pH homeostasis and longevity in response to glucose availability.

by Tobias Wilms, Erwin Swinnen, Elja Eskes, Laura Dolz-Edo, Alice Uwineza, Ruben Van Essche, Joëlle Rosseels, Piotr Zabrocki, Elisabetta Cameroni, Vanessa Franssens, Claudio De Virgilio, Gertien J Smits, Joris Winderickx
Published 2017-06-01

A Novel Tau Antibody Detecting the First Amino-Terminal Insert Reveals Conformational Differences Among Tau Isoforms

by Joke Verelst, Nick Geukens, Sabiha Eddarkaoui, Dorien Vliegen, Elien De Smidt, Joëlle Rosseels, Vanessa Franssens, Sofie Molenberghs, Cindy Francois, Erik Stoops, Maria Bjerke, Maria Bjerke, Sebastiaan Engelborghs, Sebastiaan Engelborghs, Mohamed Laghmouchi, Sofie Carmans, Luc Buée, Eugeen Vanmechelen, Joris Winderickx, Debby Thomas
Published 2020-03-01