Parp1 localizes within the Dnmt1 promoter and protects its unmethylated state by its enzymatic activity.

Parp1 localizes within the Dnmt1 promoter and protects its unmethylated state by its enzymatic activity.

Aberrant hypermethylation of CpG islands in housekeeping gene promoters and widespread genome hypomethylation are typical events occurring in cancer cells. The molecular mechanisms behind these cancer-related changes in DNA methylation patterns are not well understood. Two questions are particularly...

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Bibliographic Details
Main Authors: Michele Zampieri, Claudio Passananti, Roberta Calabrese, Mariagrazia Perilli, Nicoletta Corbi, Fabiana De Cave, Tiziana Guastafierro, Maria Giulia Bacalini, Anna Reale, Gianfranco Amicosante, Lilia Calabrese, Jordanka Zlatanova, Paola Caiafa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2650799?pdf=render

Internet

http://europepmc.org/articles/PMC2650799?pdf=render

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