Cerebrovascular pathology in Down syndrome and Alzheimer disease

Cerebrovascular pathology in Down syndrome and Alzheimer disease

Abstract People with Down syndrome (DS) are at high risk for developing Alzheimer disease (AD) with age. Typically, by age 40 years, most people with DS have sufficient neuropathology for an AD diagnosis. Interestingly, atherosclerosis and hypertension are atypical in DS with age, suggesting the lac...

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Bibliographic Details
Main Authors: Elizabeth Head, Michael J. Phelan, Eric Doran, Ronald C. Kim, Wayne W. Poon, Frederick A. Schmitt, Ira T. Lott
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Acta Neuropathologica Communications
Subjects:
Arteriolosclerosis
Atherosclerosis
Cerebral amyloid angiopathy
Trisomy 21
Vascular risk factors
Online Access:http://link.springer.com/article/10.1186/s40478-017-0499-4

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http://link.springer.com/article/10.1186/s40478-017-0499-4

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